Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.
Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.
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DOI：
10.1002/adma.202106787
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Bettinger CJ
中科院分区：
文献类型：
--
作者：
Balakrishnan G;Song J;Mou C;Bettinger CJ
设计与人体无缝结合的生物电子设备是一项非常重要的技术追求。生物电子医疗设备能够与身体长期可靠地连接，可以促进神经科学、健康监测、诊断和治疗的发展。最近的主要工作集中在研究制造柔性、可拉伸和软电子设备的策略，材料化学的进步已成为创造下一代生物电子学的基础。在这篇综述中，我们总结了与生物电子器件三个主要组成部分相关的当代进展和即将到来的技术挑战：(i) 基板和结构材料，(ii) 屏障和封装材料，以及 (iii) 导电材料。通过文献中的著名插图，强调了集成和器件制造策略以及每种材料类别的相关挑战。与人体连接的柔性、可拉伸和柔软的电子器件在解锁各种诊断、治疗和健康监测应用方面具有巨大的潜力。材料化学在确定这些设备与生物系统的相互作用和集成方面发挥着至关重要的作用。介绍了材料化学生物电子学的最新进展，并强调了挑战、机遇和未来的研究方向。
Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical devices that reliably and chronically interface with the body can advance neuroscience, health monitoring, diagnostics, and therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, and soft electronic devices, and advances in materials chemistry have emerged as fundamental to the creation of the next generation of bioelectronics. In this review, we summarize contemporary advances and forthcoming technical challenges related to three principal components of bioelectronic devices: (i) substrates and structural materials, (ii) barrier and encapsulation materials, and (iii) conductive materials. Through notable illustrations from the literature, integration and device fabrication strategies and associated challenges for each material class are highlighted. Flexible, stretchable and soft electronics interfaced with the human body hold immense potential to unlock a variety of diagnostic, therapeutic, and health monitoring applications. Materials chemistry plays a crucial role in determining the interaction and integration of these devices with biological systems. Recent progress in materials chemistry-enabled bioelectronics is presented and challenges, opportunities, and future research directions are highlighted.
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