Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review.
Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review.
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DOI：
10.1289/ehp.1104579
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发表时间：
2012-12
影响因子：
10.4
通讯作者：
Loomis D
中科院分区：
文献类型：
--
作者：
Maull EA;Ahsan H;Edwards J;Longnecker MP;Navas-Acien A;Pi J;Silbergeld EK;Styblo M;Tseng CH;Thayer KA;Loomis D
工作背景：糖尿病影响着全球约3.46亿人，预计未来十年糖尿病总死亡人数将增加> 50%。了解环境化学品在糖尿病的发展或进展中的作用是环境卫生领域的一个新问题。2011年，国家毒理学计划（NTP）组织了一次研讨会，评估文献中某些化学品（包括无机砷）与糖尿病和/或肥胖症之间的关联证据，以帮助制定重点研究议程。本审查报告是根据该讲习班的讨论编写的。目的：我们的目标是评估科学文献中关于砷和糖尿病的研究结果的一致性，优势/劣势和生物学可验证性，并确定数据差距和未来评估或研究的领域。现有文献的范围不足以将肥胖视为一种结局。数据来源、提取和合成：通过PubMed确定了与砷和糖尿病或肥胖相关的研究，并通过审查主要文献或综述文章中的参考文献列表确定了相关研究。结论：现有的人类数据为砷和糖尿病之间的关联提供了有限的充分支持，在暴露水平相对较高的人群中（饮用水中砷≥ 150 µg/L）。证据不足以得出结论，砷与糖尿病在较低的暴露量（< 150微克砷/升饮用水），虽然最近的研究结果和暴露的更好的措施支持的关联。整个动物文献尚无定论;然而，使用更好的糖尿病相关终点指标的研究支持砷与糖尿病之间的联系。
Background: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase > 50% in the next decade. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evidence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obesity to help develop a focused research agenda. This review is derived from discussions at that workshop. Objectives: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome. Data Sources, Extraction, and Synthesis: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles. Conclusions: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥ 150 µg arsenic/L in drinking water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (< 150 µg arsenic/L drinking water), although recent studies with better measures of outcome and exposure support an association. The animal literature as a whole was inconclusive; however, studies using better measures of diabetes-relevant end points support a link between arsenic and diabetes.
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影响因子：
8.3
作者：
Coronado-Gonzalez, Jose Antonio;Del Razo, Luz Maria;la Pena, Jorge Escobedo-de
通讯作者：
la Pena, Jorge Escobedo-de
影响因子：
5.1
作者：
Afridi, Hassan Imran;Kazi, Tasneem Gul;Sarfraz, Raja Adil
通讯作者：
Sarfraz, Raja Adil
DOI：
10.1007/s00244-010-9607-1
发表时间：
2011-08-01
影响因子：
4
作者：
Alicia Bartolotta, Susana;Gabriel Pacskowski, Matias;Ana Carballo, Marta
通讯作者：
Ana Carballo, Marta
影响因子：
10.4
作者：
Chen Y;Ahsan H;Slavkovich V;Peltier GL;Gluskin RT;Parvez F;Liu X;Graziano JH
通讯作者：
Graziano JH
DOI：
10.1038/jes.2008.32
发表时间：
2009-01-01
影响因子：
4.5
作者：
Caldwell, Kathleen L.;Jones, Robert L.;Osterloh, John D.
通讯作者：
Osterloh, John D.