Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats.
Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats.
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DOI：
10.1016/j.bbr.2011.12.010
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发表时间：
2012-03-17
影响因子：
2.7
通讯作者：
Zuo, Zhiyi
中科院分区：
文献类型：
--
作者：
Lin, Daowei;Cao, Lin;Wang, Zhi;Li, Jiejie;Washington, Jacqueline M.;Zuo, Zhiyi
术后认知功能障碍（POCD）是一种临床现象，已引起公众和科学界的极大关注。年龄是POCD的危险因素。然而，全身麻醉/麻醉药对POCD的贡献和潜在的神经病理学尚不清楚。在这里，我们发现，18个月大的雄性Fisher 344大鼠暴露于1.2%的异氟烷，全身麻醉剂，2小时，有显着的学习和记忆障碍，评估后2至4周异氟烷暴露。这些异氟烷效应通过静脉注射利多卡因（1.5 mg/kg推注，然后在异氟烷暴露期间2 mg/kg/h）减弱，这是一种具有神经保护作用的局部麻醉剂。暴露于异氟烷或异氟烷加利多卡因未改变神经元和突触密度以及在异氟烷暴露后29天海马中NeuN（一种神经元蛋白）、dreplatin（一种树突棘蛋白）、突触素（一种突触蛋白）、活化的半胱天冬酶3和半胱天冬酶活化的DNA酶的表达，此时存在认知障碍。在异氟烷暴露后29天，异氟烷和利多卡因不影响大脑皮质中β-淀粉样蛋白肽、总tau和磷酸化tau的量以及海马中白细胞介素-1 β和肿瘤坏死因子-α的量。因此，异氟烷诱导老年大鼠的学习和记忆障碍。利多卡因可减弱这些异氟烷效应。异氟烷可能不会引起持久的神经病理学变化。
Post-operative cognitive dysfunction (POCD) is a clinical phenomenon that has drawn significant attention from the public and scientific community. Age is a risk factor for POCD. However, the contribution of general anesthesia/anesthetics to POCD and the underlying neuropathology are not clear. Here, we showed that 18-month-old male Fisher 344 rats exposed to 1.2% isoflurane, a general anesthetic, for 2 h had significant learning and memory impairments assessed at 2 to 4 weeks after isoflurane exposure. These isoflurane effects were attenuated by intravenous lidocaine (1.5 mg/kg as a bolus and then 2 mg/kg/h during isoflurane exposure), a local anesthetic that has neuroprotective effect. Exposure to isoflurane or isoflurane plus lidocaine did not change the neuronal and synaptic density as well as the expression of NeuN (a neuronal protein), drebrin (a dendritic spine protein), synaptophysin (a synaptic protein), activated caspase 3 and caspase-activated DNase in the hippocampus at 29 days after isoflurane exposure when cognitive impairment was present. Isoflurane and lidocaine did not affect the amount of β-amyloid peptide, total tau and phospho-tau in the cerebral cortex as well as interleukin-1β and tumor necrosis factor-α in the hippocampus at 29 days after isoflurane exposure. Thus, isoflurane induces learning and memory impairment in old rats. Lidocaine attenuates these isoflurane effects. Isoflurane may not cause long-lasting neuropathological changes.
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DOI：
10.1083/jcb.107.4.1449
发表时间：
1988-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hirokawa N;Shiomura Y;Okabe S
通讯作者：
Okabe S
影响因子：
10.5
作者：
Ancelin, ML;De Roquefeuil, G;Ritchie, K
通讯作者：
Ritchie, K
影响因子：
5.7
作者：
Farag, Ehab;Chelune, Gordon J.;Mascha, Edward J.
通讯作者：
Mascha, Edward J.
影响因子：
5.7
作者：
Culley, DJ;Baxter, MG;Crosby, G
通讯作者：
Crosby, G
影响因子：
3.6
作者：
Jildenstal, Pether K.;Hallen, Jan L.;Berggren, Lars
通讯作者：
Berggren, Lars