Organized Chaos: Deciphering Immune Cell Heterogeneity's Role in Inflammation in the Heart.
Organized Chaos: Deciphering Immune Cell Heterogeneity's Role in Inflammation in the Heart.
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DOI：
10.3390/biom12010011
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发表时间：
2021-12-22
期刊：
影响因子：
5.5
通讯作者：
DeLeon-Pennell KY
中科院分区：
文献类型：
--
作者：
Corker A;Neff LS;Broughton P;Bradshaw AD;DeLeon-Pennell KY
在体内平衡期间，免疫细胞通过充当组织损伤和外来颗粒的哨兵来执行日常管家功能以维持心脏健康。常驻免疫细胞构成健康人心室组织中细胞群体的5%。作为对损伤的反应，由于免疫细胞的涌入，心脏内的炎症增加。一些最常见的免疫细胞募集到心脏是巨噬细胞，树突状细胞，中性粒细胞和T细胞。在这篇综述中，我们将讨论有关稳态期间心脏免疫细胞异质性的已知信息、这些细胞群如何响应心肌梗死或压力超负荷等病理变化，以及哪些刺激正在调节这些过程。此外，我们将总结用于评估心血管疾病模型中细胞异质性的技术。
During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular tissue. In response to injury, there is an increase in inflammation within the heart due to the influx of immune cells. Some of the most common immune cells recruited to the heart are macrophages, dendritic cells, neutrophils, and T-cells. In this review, we will discuss what is known about cardiac immune cell heterogeneity during homeostasis, how these cell populations change in response to a pathology such as myocardial infarction or pressure overload, and what stimuli are regulating these processes. In addition, we will summarize technologies used to evaluate cell heterogeneity in models of cardiovascular disease.
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影响因子：
6.4
作者：
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通讯作者：
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影响因子：
37.8
作者：
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DOI：
10.1016/j.jasms.2006.04.026
发表时间：
2006-08-01
影响因子：
3.2
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Reik W
DOI：
10.1007/s12265-012-9365-8
发表时间：
2012-06-01
影响因子：
3.4
作者：
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通讯作者：
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