Chemical evaluation of electronic cigarettes.

Chemical evaluation of electronic cigarettes.
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DOI:
10.1136/tobaccocontrol-2013-051482
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发表时间:
2014-05
期刊:
影响因子:
5.2
通讯作者:
Cheng T
Cheng T
中科院分区:
医学2区
文献类型:
--
作者:
Cheng T

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审查现有证据,评估电子烟(电子烟)的再填充溶液、烟弹、气溶胶和环境排放物中的化学物质。使用5个参考数据库和11个检索词进行了系统的文献检索,以确定与电子烟和化学相关的研究。检索日期范围为2007年1月至2013年9月。检索得到36篇文章,其中29篇被认为与分析相关。尼古丁、烟草特有的亚硝胺(TSNAs)、醛类、金属、挥发性有机化合物(VOCs)、香料、溶剂载体和烟草生物碱在电子烟再填充溶液、烟弹、气溶胶和环境排放物中的含量差异很大。尼古丁的释放和TSNA、醛类和金属的释放在不同产品中并不一致。此外,电子烟墨盒和再填充溶液的标签上列出的尼古丁水平通常与测量值显著不同。酚类化合物、多环芳烃和药物也被报道存在于电子烟再填充溶液、烟弹和气溶胶中。已经观察到不同研究中电子烟的特定物质排放物的粒度分布的不同结果。用于气溶胶生成和化学分析的方法因研究而异。电子烟设备的性能特征在品牌之间和品牌内部也各不相同。基于对电子烟用户行为的了解以及经科学验证的气溶胶生成和化学分析方法的进一步研究将有助于产生可靠的化学量测量。这将允许比较电子烟气溶胶和传统烟雾成分水平,并为评估电子烟的潜在毒性提供信息。
To review the available evidence evaluating the chemicals in refill solutions, cartridges, aerosols and environmental emissions of electronic cigarettes (e-cigarettes). Systematic literature searches were conducted to identify research related to e-cigarettes and chemistry using 5 reference databases and 11 search terms. The search date range was January 2007 to September 2013. The search yielded 36 articles, of which 29 were deemed relevant for analysis. The levels of nicotine, tobacco-specific nitrosamines (TSNAs), aldehydes, metals, volatile organic compounds (VOCs), flavours, solvent carriers and tobacco alkaloids in e-cigarette refill solutions, cartridges, aerosols and environmental emissions vary considerably. The delivery of nicotine and the release of TSNAs, aldehydes and metals are not consistent across products. Furthermore, the nicotine level listed on the labels of e-cigarette cartridges and refill solutions is often significantly different from measured values. Phenolic compounds, polycyclic aromatic hydrocarbons and drugs have also been reported in e-cigarette refill solutions, cartridges and aerosols. Varying results in particle size distributions of particular matter emissions from e-cigarettes across studies have been observed. Methods applied for the generation and chemical analyses of aerosols differ across studies. Performance characteristics of e-cigarette devices also vary across and within brands. Additional studies based on knowledge of e-cigarette user behaviours and scientifically validated aerosol generation and chemical analysis methods would be helpful in generating reliable measures of chemical quantities. This would allow comparisons of e-cigarette aerosol and traditional smoke constituent levels and would inform an evaluation of the toxicity potential of e-cigarettes.
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