On the role of intrinsic and extrinsic forces in early cardiac S-looping.
On the role of intrinsic and extrinsic forces in early cardiac S-looping.
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DOI：
10.1002/dvdy.23968
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发表时间：
2013-07
影响因子：
2.5
通讯作者：
Gordon, Shaun S.
中科院分区：
文献类型：
--
作者：
Ramasubramanian, Ashok;Chu-Lagraff, Quynh B.;Buma, Takashi;Chico, Kevin T.;Carnes, Meagan E.;Burnett, Kyra R.;Bradner, Sarah A.;Gordon, Shaun S.
成环是心脏发育过程中的一个关键阶段，最初笔直的心管转变为更接近成熟心脏的形状。虽然心脏循环的遗传和生化途径得到了很好的研究，但实际影响循环过程的生物物理机制仍然知之甚少。使用相结合的实验（鸡胚）和计算（有限元建模）的方法，我们研究的力量驱动早期S-循环时，原始心室移动到其最终位置低于共同心房。我们研究的新结果表明，原始心脏没有形成s环的内在能力，而外力对早期s环的影响是必要的。他们支持以前的研究，建立了一个重要的作用，颈曲引起早期心脏s环。我们的研究结果还表明，在早期的s-循环和揭示的心脏果冻的作用，所施加的力的内脏不能被忽略。利用现有的实验数据和计算机建模，我们成功地开发和测试了驱动S-环形成的力机制的假设。在心脏循环的后期阶段，原始心管外部的力是必要的。实验和模型的结果支持我们提出的假设驱动力早期s-循环。
Looping is a crucial phase during heart development when the initially straight heart tube is transformed into a shape that more closely resembles the mature heart. Although the genetic and biochemical pathways of cardiac looping are well-studied, the biophysical mechanisms that actually effect the looping process remain poorly understood. Using a combined experimental (chick embryo) and computational (finite element modeling) approach, we study the forces driving early s-looping when the primitive ventricle moves to its definitive position inferior to the common atrium. New results from our study indicate that the primitive heart has no intrinsic ability to form an s-loop and that extrinsic forces are necessary to effect early s-looping. They support previous studies that established an important role for cervical flexure in causing early cardiac s-looping. Our results also show that forces applied by the splanchnopleure cannot be ignored during early s-looping and shed light on the role of cardiac jelly. Using available experimental data and computer modeling, we successfully developed and tested a hypothesis for the force mechanisms driving s-loop formation. Forces external to the primitive heart tube are necessary in the later stages of cardiac looping. Experimental and model results support our proposed hypothesis for forces driving early s-looping.
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影响因子：
2.7
作者：
Aleksandrova A;Czirók A;Szabó A;Filla MB;Hossain MJ;Whelan PF;Lansford R;Rongish BJ
通讯作者：
Rongish BJ
影响因子：
--
作者：
Linask KK;Vanauker M
通讯作者：
Vanauker M
影响因子：
20.1
作者：
BALDWIN, HS;LLOYD, TR;SOLURSH, M
通讯作者：
SOLURSH, M
影响因子：
--
作者：
Barry, A
通讯作者：
Barry, A
影响因子：
--
作者：
Bremer, JL
通讯作者：
Bremer, JL