Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation.
Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation.
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DOI：
10.1016/j.envres.2012.05.004
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发表时间：
2012-08
影响因子：
8.3
通讯作者：
Leaderer, Brian P.
中科院分区：
文献类型：
--
作者：
Bell, Michelle L.;Belanger, Kathleen;Ebisu, Keita;Gent, Janneane F.;Leaderer, Brian P.
空气中的颗粒与许多健康影响有关，包括不良妊娠结局。尽管颗粒的化学结构差异很大，但大多数颗粒研究都检查了总质量。我们调查了母亲在怀孕期间接触空气细颗粒物 (PM2.5) 中的钾 (K) 和钛 (Ti) 成分是否与足月婴儿的出生体重或低出生体重（<2500 克）风险相关。研究对象为 2000 年 8 月至 2004 年 2 月期间在美国康涅狄格州和马萨诸塞州四个县出生的 76,788 名婴儿。K 和 Ti 均与出生体重相关。四分位距 (IQR) 增加 K 与低出生体重风险增加 8.75%（95% 置信区间 (CI)：1.24–16.8%）相关。 Ti IQR 增加与低出生体重风险增加 12.1%（95% CI：3.55-21.4%）相关，估计男性为 6.41%（95% CI：-5.80-20.2%），女性为 16.4%（95% CI：5.13-28.9%）。结果仅对第一胎的敏感性分析是稳健的，但对共污染物的调整则不然。由于来源相似，某些成分之间存在协方差，因此理清各种化学成分的影响具有挑战性。尽管置信区间重叠，但非裔美国母亲的婴儿的中心效应估计值高于白人母亲的婴儿。我们的研究结果表明，怀孕期间接触空气中的钾和钛与较低的出生体重有关。关联可能与产生 K 和 Ti 的来源的化学成分有关。
Airborne particles are linked to numerous health impacts, including adverse pregnancy outcomes. Most studies of particles examined total mass, although the chemical structure of particles varies widely. We investigated whether mother’s exposure to potassium (K) and titanium (Ti) components of airborne fine particulate matter (PM2.5) during pregnancy was associated with birth weight or risk of low birth weight (<2500 gm) for term infants. The study population was 76,788 infants born in four counties in Connecticut and Massachusetts, US, for August 2000-February 2004. Both K and Ti were associated with birth weight. An interquartile range (IQR) increase K was associated with an 8.75% (95% confidence interval (CI): 1.24–16.8%) increase in risk of low birth weight. An IQR increase in Ti was associated with a 12.1% (95% CI: 3.55–21.4%) increase in risk of low birth weight, with an estimate of 6.41% (95% CI: −5.80–20.2%) for males and 16.4% (95% CI: 5.13–28.9%) for females. Results were robust to sensitivity analysis of first births only, but not adjustment by co-pollutants. Disentangling the effects of various chemical components is challenging because of the covariance among some components due to similar sources. Central effect estimates for infants of African-American mothers were higher than those of white mothers, although the confidence intervals overlapped. Our results indicate that exposure to airborne potassium and titanium during pregnancy is associated with lower birth weight. Associations may relate to chemical components of sources producing K and Ti.
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空气颗粒物污染会导致婴儿死亡吗？系统回顾。
影响因子：
10.4
作者：
Glinianaia, SV;Rankin, J;Bell, R;Pless-Mulloli, T;Howel, D
通讯作者：
Howel, D
影响因子：
10.4
作者：
Ito K;Mathes R;Ross Z;Nádas A;Thurston G;Matte T
通讯作者：
Matte T
影响因子：
10.4
作者：
Clougherty JE
通讯作者：
Clougherty JE
美国健康效应研究中PM（2.5）化学成分的空间和时间变化。
影响因子：
10.4
作者：
Bell ML;Dominici F;Ebisu K;Zeger SL;Samet JM
通讯作者：
Samet JM
DOI：
10.1097/ede.0b013e3181f2f405
发表时间：
2010-11
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bell ML;Belanger K;Ebisu K;Gent JF;Lee HJ;Koutrakis P;Leaderer BP
通讯作者：
Leaderer BP