Hyaluronic acid concentration in liver diseases.
Hyaluronic acid concentration in liver diseases.
复制标题
肝病中的透明质酸浓度。
DOI：
10.1007/s10238-015-0388-8
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发表时间：
2016-11
影响因子：
4.6
通讯作者：
Chrostek, Lech
中科院分区：
文献类型：
--
作者：
Gudowska, Monika;Gruszewska, Ewa;Panasiuk, Anatol;Cylwik, Bogdan;Flisiak, Robert;Aewiderska, Magdalena;Szmitkowski, Maciej;Chrostek, Lech
本研究旨在探讨不同病因及临床严重程度的肝病对血清透明质酸水平的影响。与无创肝纤维化指标APRI、GAPRI、HAPRI、FIB-4、Forn‘s指数进行比较。20例健康志愿者和酒精性肝硬变(AC)患者57例，非酒精性肝硬变(NAC)30例，中毒性肝炎(HT)22例。根据Child-Pugh评分对肝硬变患者进行分级。免疫化学法测定透明质酸浓度。非专利指标是使用特殊公式计算的。AC组、NAC组和HT组血清透明质酸平均浓度显著高于对照组。不同肝病患者血清透明质酸水平差异有统计学意义，AC组血清透明质酸水平显著高于NAC组和HT组。血清透明质酸水平因肝硬变严重程度不同而有显著差异，且在Child-Pugh C级中最高。透明质酸和所有非专利算法的灵敏度、特异度、准确性、阳性预测值和阴性预测值以及ROC曲线下面积都很高，且彼此相似。提示透明质酸浓度在肝病中发生变化，并受肝硬变严重程度的影响。血清透明质酸可作为无创性诊断肝损伤的良好标志物，但联合应用更有价值。
The aim of this study was to evaluate the effect of liver diseases of different etiologies and clinical severity of liver cirrhosis on the serum level of hyaluronic acid. The results were compared with noninvasive markers of liver fibrosis: APRI, GAPRI, HAPRI, FIB-4 and Forn’s index. Serum samples were obtained from 20 healthy volunteers and patients suffering from alcoholic cirrhosis (AC)—57 patients, non-alcoholic cirrhosis (NAC)—30 and toxic hepatitis (HT)—22. Cirrhotic patients were classified according to Child–Pugh score. Hyaluronic acid concentration was measured by the immunochemical method. Non-patented indicators were calculated using special formulas. The mean serum hyaluronic acid concentration was significantly higher in AC, NAC and HT group in comparison with the control group. There were significant differences in the serum hyaluronic acid levels between liver diseases, and in AC they were significantly higher than those in NAC and HT group. The serum hyaluronic acid level differs significantly due to the severity of cirrhosis and was the highest in Child–Pugh class C. The sensitivity, specificity, accuracy, positive and negative predictive values and the area under the ROC curve for hyaluronic acid and all non-patented algorithms were high and similar to each other. We conclude that the concentration of hyaluronic acid changes in liver diseases and is affected by the severity of liver cirrhosis. Serum hyaluronic acid should be considered as a good marker for noninvasive diagnosis of liver damage, but the combination of markers is more useful.
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影响因子：
13.5
作者：
Rockey, DC;Bissell, DM
通讯作者：
Bissell, DM
影响因子：
25.7
作者：
Korner, T;Kropf, J;Gressner, AM
通讯作者：
Gressner, AM
DOI：
10.1111/j.1530-0277.1993.tb05655.x
发表时间：
1993-10-01
影响因子：
3.2
作者：
DEACIUC, IV;MCDONOUGH, KH;SPITZER, JJ
通讯作者：
SPITZER, JJ
DOI：
10.1016/0928-4346(94)90016-7
发表时间：
1994-02-15
期刊：
INTERNATIONAL HEPATOLOGY COMMUNICATIONS
影响因子：
--
作者：
DEACIUC, IV;SPITZER, JJ;DSOUZA, NB
通讯作者：
DSOUZA, NB
DOI：
10.1097/00042737-200309000-00002
发表时间：
2003-09-01
影响因子：
2.1
作者：
Stickel, F;Poeschl, G;Seitz, HK
通讯作者：
Seitz, HK