Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study.
Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study.
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DOI：
10.1136/bmjopen-2014-006071
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发表时间：
2014-11-11
期刊：
影响因子：
2.9
通讯作者：
Khaw KT
中科院分区：
文献类型：
--
作者：
Leng Y;Ahmadi-Abhari S;Wainwright NW;Cappuccio FP;Surtees PG;Luben R;Brayne C;Khaw KT
在英国老年人群中，探讨白天小睡和睡眠时间是否与血清C反应蛋白（CRP）（一种促炎标志物）有关。横断面研究。欧洲癌症与营养前瞻性调查（EPIC）-诺福克研究。共有5018名48-92岁的男性和女性报告了他们的睡眠习惯，并测量了血清CRP水平。 在2006-2011年期间，使用高灵敏度方法测量新鲜血液样本中的CRP（mg/L）。参与者报告了2002-2004年的午睡习惯，并报告了2006-2007年的睡眠量。多变量线性回归模型用于检查打盹和对数转换的CRP之间的关联，并计算CRP水平的几何平均值。在调整年龄和性别后，那些报告午睡的人的CRP水平比那些不午睡的人高10%。在进一步调整社会阶层、教育、婚姻状况、体重指数、体力活动、吸烟、饮酒、自我报告的健康状况、既存疾病、收缩压、催眠药物使用、抑郁症和仅女性激素替代治疗使用后，这种关联减弱，但仍具有边缘显著性（β=0.05（95%CI 0.00至0.10））。报告午睡和无午睡的受试者CRP水平的几何平均值（95%CI）分别为2.38（2.29至2.47）mg/L和2.26（2.21至2.32）mg/L。观察到夜间卧床时间与CRP水平之间呈U型相关，夜间睡眠时间与血清CRP水平无关。对于年龄较大的参与者来说，午睡和CRP之间的联系更强，并且在晚上睡觉的极端时间中。在英国老年人群中，白天小睡与CRP水平升高相关。需要进一步的研究来确定白天小睡是否是全身炎症的原因，或者它是否是潜在健康问题的症状或后果。
To explore whether daytime napping and sleep duration are linked to serum C reactive protein (CRP), a pro-inflammatory marker, in an older aged British population. Cross-sectional study. European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study. A total of 5018 men and women aged 48–92 years reported their sleep habits and had serum CRP levels measured. CRP was measured (mg/L) during 2006–2011 in fresh blood samples using high-sensitivity methods. Participants reported napping habits during 2002–2004, and reported sleep quantity during 2006–2007. Multivariable linear regression models were used to examine the association between napping and log-transformed CRP, and geometric mean CRP levels were calculated. After adjustment for age and sex, those who reported napping had 10% higher CRP levels compared with those not napping. The association was attenuated but remained borderline significant (β=0.05 (95% CI 0.00 to 0.10)) after further adjustment for social class, education, marital status, body mass index, physical activity, smoking, alcohol intake, self-reported health, pre-existing diseases, systolic blood pressure, hypnotic drug use, depression and in women-only hormone replacement therapy use. The geometric means (95% CI) of CRP levels were 2.38 (2.29 to 2.47) mg/L and 2.26 (2.21 to 2.32) mg/L for those who reported napping and no napping, respectively. A U-shaped association was observed between time spent in bed at night and CRP levels, and nighttime sleep duration was not associated with serum CRP levels. The association between napping and CRP was stronger for older participants, and among extremes of time spent in bed at night. Daytime napping was associated with increased CRP levels in an older aged British population. Further studies are needed to determine whether daytime napping is a cause for systemic inflammation, or if it is a symptom or consequence of underlying health problems.
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影响因子：
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作者：
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通讯作者：
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作者：
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