Histological and computed tomographic characteristics of the sinonasal structure of BALB/c mice

Histological and computed tomographic characteristics of the sinonasal structure of BALB/c mice
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BALB/c小鼠鼻腔结构的组织学和计算机断层扫描特征

DOI:
10.1111/ahe.12516
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发表时间:
2019-11
期刊:
Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C
影响因子:
--
通讯作者:
Zhang Gehua
Zhang Gehua
中科院分区:
其他
文献类型:
--
作者:
Wang Zhiyuan;Chang Lihong;Huang Jiancong;Huang Zizhen;Li Xia;Chen Xiaohong;Lai Xiaoping;Zhang Gehua

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小鼠模型用于研究小鼠和人类疾病的发病机制。虽然已经报道了一些变应性鼻炎和鼻窦炎的小鼠模型,但文献中没有详细的正常小鼠鼻窦的解剖学、组织学和计算机断层扫描比较数据可供新的研究者建立小鼠模型。本研究的目的是阐明BALB/c小鼠正常鼻窦的组织学和CT特征。收集了15个鼻窦标本。对5只小鼠进行显微计算机断层扫描成像,然后解剖观察其解剖标志,并对10只小鼠进行苏木精和伊红染色。重要解剖标志包括筛鼻甲、鼻鼻甲、上鼻甲、筛窦、上颌窦、鼻咽管、鼻泪管和犁鼻器。通过大体解剖、显微计算机断层扫描成像和苏木精-伊红染色可以显示完整和典型的鼻窦标志,这将有助于建立鼻疾病的小鼠模型。
Mice models were used to study the pathogenesis of mice and human diseases. Although some mice models of allergic rhinitis and rhinosinusitis have been reported, no detailed anatomic, histological and computed tomographic comparative data of the normal murine sinus are available in the literature for new researchers to establish mice models. The purpose of this study was to clarify the histological and computed tomographic characteristics of the normal nasal sinus in BALB/c mice. Fifteen sinonasal specimens were collected. Five mice were subjected to micro‐computed tomography imaging, and then dissected to observe its anatomic landmarks, and 10 mice were subjected to haematoxylin and eosin staining. Important anatomic landmarks were clearly demonstrated, including the ethmoturbinates, nasoturbinal, maxilloturbinate, ethmoid sinus, maxillary sinus, nasopharyngeal duct, nasolacrimal duct and vomeronasal organ. Full and typical sinonasal landmarks can be visualized by gross anatomy, micro‐computed tomography imaging and haematoxylin and eosin staining, which will be useful for establishing the mouse models of nasal disease.
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发表时间: 2013-07-01
期刊: ALLERGY
影响因子: 12.4
作者:
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