Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults.
Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults.
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DOI：
10.3389/fpsyg.2022.712660
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发表时间：
2022
影响因子：
3.8
通讯作者：
Méndez-Chacón E
中科院分区：
文献类型：
--
作者：
Méndez-Chacón E
应激与疾病和白细胞端粒长度（LTL）减少有关。本研究的目的是确定自我感知的压力是否与哥斯达黎加成年人的端粒长度有关，以及这种关系的性别差异。研究结果可能有助于解释为什么一些明显处于社会经济劣势和获得专业医疗服务的机会有限的人口的预期寿命非常高。数据来自哥斯达黎加长寿和健康老龄化研究（CRELES）的退休前队列，这是一项在家庭中对2,327名53至66岁的成年人进行的人口调查。用于测量LTL的DNA是从哥斯达黎加大学实验室的血细胞中提取的，而加利福尼亚大学的布莱克本实验室则使用定量聚合酶链反应（Q-PCR）进行端粒长度测量。端粒长度与感知压力之间的关系采用最小二乘多元回归测量。感知压力是通过一系列关于家庭、工作、财务和健康原因的问题来衡量的。模型包括控制变量：(1)参与者的年龄和性别，(2)他或她是否居住在Nicoya地区，这是一个以长寿而闻名的“蓝色区域”，以及(3)上述社会人口、健康和生活方式特征。压力感知和LTL在性别上存在显著差异。除了工作之外，女性在研究的几乎所有方面都比男性感受到更大的压力。女性的端粒明显更长。较短的端粒与男性的照顾压力和女性的父母健康问题显著相关。在照顾家庭成员感到压力的女性中，观察到与直觉相反的端粒延长；在那些因为家庭关系和担心自己健康而感到压力的男性中。研究结果证实，那些因照顾他人或健康问题而感到压力的人端粒更短。压力和端粒长度之间的关系在男性和女性之间是不同的。性别关系对压力与LTL之间的关系具有较强的调节作用：性别与感知压力、端粒长度有关，并明显与压力与LTL的关系方式有关。
Stress is associated with disease and reduced leukocyte telomere length (LTL). The objective of this research is to determine if self-perceived stress is associated with telomere length in Costa Rican adults and the gender differences in this association. Findings may help explain how some populations in apparent socioeconomic disadvantage and with limited access to specialized medical services have a remarkably high life expectancy. Data come from the pre-retirement cohort of the Costa Rican Longevity and Healthy Aging Study (CRELES), a population based survey conducted in the households to 2,327 adults aged 53 to 66 years. The DNA to measure LTL was extracted from blood cells in laboratories of the University of Costa Rica whereas the Blackburn laboratory at the University of California performed the telomere length measurement applying the quantitative polymerase chain reaction (Q-PCR). The relationship between telomere length and perceived stress was measured using least-squares multiple regression. Perceived stress was measured by a set of questions about family, job, finances and, health reasons to be stressed. Models included the control variables: (1) age and sex of the participant, (2) whether he or she resides in the Nicoya area, a “blue zone” known for its high longevity, and (3) the aforementioned sociodemographic, health and lifestyles characteristics. Stress perception and LTL are significantly different by sex. Women perceived higher stress levels than men in almost all aspects studied, except work. Women have significantly longer telomeres. Shorter telomeres are significantly associated with caregiving stress in men and with parental health concerns in women. Counter-intuitive telomere lengthenings were observed among women who feel stressed about caring for family members; and among men who feel stressed due to their family relationships as well as concerns about their own health. Results confirm that people with self-perceived stress due to caregiving or health issues have shorter telomeres. The relationship between stress and telomere length differs between men and women. Gender relations exert a strong modifier effect on the relationship between stress and LTL: gender is related to perceived stress, telomere length, and apparently also to the way stress and LTL are related.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
影响因子：
1.3
作者：
Vasunilashorn S;Cohen AA
通讯作者：
Cohen AA
影响因子：
8
作者：
Drury, Stacy S.;Mabile, Emily;Theall, Katherine P.
通讯作者：
Theall, Katherine P.
影响因子：
15.1
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
通讯作者：
Effros, Rita B.