Stress responsive biochemical anabolic/catabolic ratio and telomere length in older adults.
Stress responsive biochemical anabolic/catabolic ratio and telomere length in older adults.
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DOI：
10.1080/19485565.2014.950722
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发表时间：
2014
影响因子：
1.3
通讯作者：
Cohen AA
中科院分区：
文献类型：
--
作者：
Vasunilashorn S;Cohen AA
有人假设慢性心理应激与较短的端粒长度有关；然而，应激与端粒长度之间的联系机制还不是很清楚。为探讨应激觉醒与细胞老化相关的生化因素之间的相互作用，我们在台湾社会环境与老化生物标记物研究(SEBAS)中调查了合成/分解代谢(A/C)失衡与白细胞端粒长度(LTL)的关系(N=925)。SEBAS受试者年龄在54岁及以上(平均年龄68.3岁)，检测两种合成代谢激素(血清脱氢表雄酮硫酸盐[DHEAS]和胰岛素生长因子[IGF]-1)、四种分解代谢激素(皮质醇、肾上腺素、去甲肾上腺素和白细胞介素6[IL-6])和白细胞端粒长度。我们发现高IL-6与较短的LTL相关(≤0.88T/S比值；优势比[OR]1.41，95%可信区间[CI]1.04~1.92)。DHEAS/皮质醇和IGF-1/皮质醇比值均与端粒长度无关；然而，高A/C失衡总分与较短LTL相对较长LTL的几率更大(OR 1.19，95%CI 1.05~1.35)。这些结果表明，我们的A/C失衡分数，由几个合成代谢和分解代谢生化因素定义，可能是心理应激与白细胞端粒长度较短以及可能的细胞衰老有关的机制之一。
It has been hypothesized that chronic psychological stress is associated with shorter telomere length; however, the mechanisms that link stress and telomere length are not well understood. To examine the interplay between biochemical factors related to stress arousal and cellular aging, we investigate the association between anabolic/catabolic (A/C) imbalance and leukocyte telomere length (LTL) in the Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan (N=925). SEBAS participants age 54 and older (mean age 68.3) with values for two anabolic hormones (serum dehydroepiandrosterone sulfate [DHEAS] and insulin growth factor [IGF]-1), four catabolic hormones (cortisol, epinephrine, norepinephrine, and interleukin-6 [IL-6]), and leukocyte telomere length were examined. We found that high IL-6 was associated with short LTL (≤0.88 T/S ratio; odds ratio [OR] 1.41, 95% confidence interval [CI] 1.04–1.92). Neither DHEAS/cortisol nor IGF-1/cortisol ratio was associated with telomere length; however, a high A/C imbalance summary score was associated with a greater odds of having a short LTL relative to long LTL (OR 1.19, 95% CI 1.05–1.35). These results indicate that our A/C imbalance score, defined by several anabolic and catabolic biochemical factors, may be one mechanism through which psychological stress is associated with short leukocyte telomere length and possibly cellular senescence.
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影响因子：
--
作者：
Maggio, Marcello;Lauretani, Fulvio;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
3.9
作者：
Dowd, Jennifer B.;Bosch, Jos A.;Aiello, Allison E.
通讯作者：
Aiello, Allison E.
影响因子：
15.1
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
通讯作者：
Effros, Rita B.
影响因子：
3.7
作者：
Cruess, DG;Antoni, MH;Schneider, N
通讯作者：
Schneider, N
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM