Rapid HIV Viral Load Suppression in those Initiating Antiretroviral Therapy at First Visit after HIV Diagnosis.
Rapid HIV Viral Load Suppression in those Initiating Antiretroviral Therapy at First Visit after HIV Diagnosis.
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DOI：
10.1038/srep32947
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发表时间：
2016-09-06
影响因子：
4.6
通讯作者：
Little SJ
中科院分区：
文献类型：
--
作者：
Hoenigl M;Chaillon A;Moore DJ;Morris SR;Mehta SR;Gianella S;Amico KR;Little SJ
抗逆转录病毒治疗（ART）的专家指南现在建议所有艾滋病毒感染者尽快接受ART治疗，以减少疾病进展的风险并预防传播。这项观察性研究的目的是评估非常早期开始ART和方案类型对病毒抑制时间的影响。我们评估了86名新诊断的HIV感染者在诊断后30天内开始ART的病毒抑制时间。共有36例（42%）为急性，27例（31%）为早期，23例（27%）为已确定的HIV感染。从立即提供抗逆转录病毒治疗到开始抗逆转录病毒治疗的中位时间为8天。总共有56/86（65%）人开始了基于整合酶的方案，30/86（35%）人开始了基于蛋白酶的方案。接受整合酶抑制剂治疗的患者至病毒抑制的时间显著短于接受蛋白酶抑制剂治疗的患者（p = 0.022）。22名（26%）在HIV护理就诊时开始ART，其中79%的参与者在第12周达到病毒抑制，第24周为82%，第48周为88%。在就诊时开始的抗逆转录病毒治疗可在急性、早期和慢性HIV感染中实现快速可靠的病毒抑制，特别是在使用基于整合酶受体的治疗方案时。
Expert guidelines for antiretroviral therapy (ART) now recommend ART as soon as possible in all HIV infected persons to reduce the risk of disease progression and prevent transmission. The goal of this observational study was to evaluate the impact of very early ART initiation and regimen type on time to viral suppression. We evaluated time to viral suppression among 86 persons with newly-diagnosed HIV infection who initiated ART within 30 days of diagnosis. A total of 36 (42%) had acute, 27 (31%) early, and 23 (27%) had established HIV infection. The median time from an offer of immediate ART to starting ART was 8 days. A total of 56/86 (65%) initiated an integrase inhibitor-based regimen and 30/86 (35%) a protease inhibitor-based regimen. The time to viral suppression was significantly shorter in those receiving an integrase inhibitor- versus a protease inhibitor-based regimen (p = 0.022). Twenty-two (26%) initiated ART at their HIV care intake visit and 79% of these participants achieved viral suppression at week 12, 82% at week 24 and 88% at week 48. ART initiated at the intake visit led to rapid and reliable viral suppression in acute, early and chronic HIV infection, in particular when integrase inhibitor-based regimens were used.
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DOI：
10.1073/pnas.97.7.3382
发表时间：
2000-03-28
影响因子：
11.1
作者：
Oxenius, A;Price, DA;Phillips, RE
通讯作者：
Phillips, RE
影响因子：
1.2
作者：
Gianella, Sara;von Wyl, Viktor;Guenthard, Huldrych F.
通讯作者：
Guenthard, Huldrych F.
DOI：
10.1097/qai.0000000000000575
发表时间：
2015-05-01
影响因子：
3.6
作者：
Castel, Amanda D.;Tang, Wenze;Greenberg, Alan
通讯作者：
Greenberg, Alan
DOI：
10.1097/qai.0000000000000616
发表时间：
2015-08-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Halkitis P;Kapadia F;Ompad D
通讯作者：
Ompad D
在圣地亚哥接受社区测试的年轻人的艾滋病毒感染率和风险行为。
影响因子：
4.6
作者：
Hoenigl M;Chaillon A;Morris SR;Little SJ
通讯作者：
Little SJ