Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT).
Regulation of miRNA expression by low-level laser therapy (LLLT) and photodynamic therapy (PDT).
复制标题
DOI：
10.3390/ijms140713542
复制
发表时间：
2013-06-27
影响因子：
5.6
通讯作者：
Ishihara M
中科院分区：
文献类型：
--
作者：
Kushibiki T;Hirasawa T;Okawa S;Ishihara M
激光疗法的应用，包括低水平激光疗法（LLLT）、光疗和光动力疗法（PDT），已被证明是用于许多疾病和疾病状况的有益且相对侵入性较小的治疗方式。使用特定类型的激光照射，可以诱导特定的细胞活动。由于多个细胞信号级联在暴露于激光的细胞中同时被激活，因此了解细胞内的分子反应将有助于激光疗法的发展。为了详细了解LLLT和PDT相关反应的分子机制，表征miRNA和蛋白质的特异性表达将是有用的。这种分析将为激光治疗的新应用以及个性化治疗的发展提供重要来源。尽管几种miRNA在LLLT、光疗和PDT刺激下上调或下调，但很少有发表的研究涉及激光治疗对miRNA表达的影响。本文就LLLT、光疗和PDT作为代表性的激光治疗方法对miRNA表达的影响进行综述。
Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activities can be induced. Because multiple cellular signaling cascades are simultaneously activated in cells exposed to lasers, understanding the molecular responses within cells will aid in the development of laser therapies. In order to understand in detail the molecular mechanisms of LLLT and PDT-related responses, it will be useful to characterize the specific expression of miRNAs and proteins. Such analyses will provide an important source for new applications of laser therapy, as well as for the development of individualized treatments. Although several miRNAs should be up- or down-regulated upon stimulation by LLLT, phototherapy and PDT, very few published studies address the effect of laser therapy on miRNA expression. In this review, we focus on LLLT, phototherapy and PDT as representative laser therapies and discuss the effects of these therapies on miRNA expression.
登录
查看更多内容
影响因子：
--
作者：
Cavalcanti de Sousa, Ana Paula;Santos, Jean N.;Pinheiro, Antonio L. B.
通讯作者：
Pinheiro, Antonio L. B.
影响因子：
2.1
作者：
Bernardes da Silva, Ana Paula R.;Petri, Alice D.;Sasso Stuani, Maria Bernadete
通讯作者：
Sasso Stuani, Maria Bernadete
影响因子：
5.6
作者：
Aimbire, F.;Santos, F. V.;Pacheco-Soares, C.
通讯作者：
Pacheco-Soares, C.
DOI：
10.1007/978-1-60761-697-9_2
发表时间：
2010-01-01
期刊：
PHOTODYNAMIC THERAPY: METHODS AND PROTOCOLS
影响因子：
--
作者：
Dewaele, Michael;Verfaillie, Tom;Agostinis, Patrizia
通讯作者：
Agostinis, Patrizia
影响因子：
9.7
作者：
Anand, Sanjay;Ortel, Bernhard J.;Pereira, Stephen P.;Hasan, Tayyaba;Maytin, Edward V.
通讯作者：
Maytin, Edward V.