Human Milk and Preterm Infant Brain Development: A Narrative Review.
Human Milk and Preterm Infant Brain Development: A Narrative Review.
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DOI：
10.1016/j.clinthera.2022.02.011
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发表时间：
2022-04
影响因子：
3.2
通讯作者：
Inder, Terrie E.
中科院分区：
文献类型：
--
作者：
Belfort, Mandy Brown;Inder, Terrie E.
回顾并综合有关母乳和早产儿大脑结构发育及损伤的文献，重点关注定量脑磁共振成像（MRI）在该领域的应用。对 1990 年至 2021 年发表的文献进行叙述性回顾，并被 PubMed 索引，并报告了母乳或捐赠乳与早产儿大脑发育和/或损伤相关的观察或介入研究，并在足月相当年龄时使用定量 MRI 进行评估。研究的特征包括研究设计、牛奶暴露定义和 MRI 结果的关键方面。我们确定了七项相关研究，所有这些研究都是观察性设计，并于 2013 年至 2021 年间发表。其中包括妊娠 33 周或以下出生的早产儿。样本量范围为 22 至 377 名婴儿。接触母乳包括母乳和捐赠乳。没有研究包括足月对照组。主要 MRI 结果领域是：1）白质完整性，通过扩散张量成像、静息状态功能连接或白质异常的半自动分割进行评估，2）总脑容量和局部脑容量。研究表明，与配方奶相比，更多地接触母乳与良好的结果相关，包括：1）大脑白质更加成熟和相连，损伤更少； 2）更大的区域脑体积，特别是深部核灰质、杏仁核-海马和小脑。母乳暴露没有一致的标志性效应，相反，有益的关联是对早产儿已知脆弱区域的区域和组织特异性神经保护作用。迄今为止的证据表明，母乳可以保护早产儿免受白质损伤和成熟不良的影响，而这些人群很容易遭受这些损伤。足月当量年龄的脑部 MRI 正在成为研究母乳对早产儿大脑影响的有用工具。当以早产儿脑损伤和发育的神经生物学知识为基础时，这种方法有望进一步深入了解母乳与该人群神经发育结果有益关联的机制和途径，并研究具有神经保护或神经恢复潜力的特定母乳生物活性成分。
To review and synthesize the literature on human milk and structural brain development and injury in preterm infants, focusing on the application of quantitative brain magnetic resonance imaging (MRI) in this field. Narrative review of the literature published from 1990 to 2021, indexed in PubMed, and reporting observational or interventional studies of maternal milk or donor milk in relation to brain development and/or injury in preterm infants, assessed with quantitative MRI at term equivalent age. Studies were characterized with respect to key aspects of study design, milk exposure definition, and MRI outcomes. We identified seven relevant studies, all of which were observational in design and published between 2013 and 2021. Included preterm infants were born at or below 33 weeks’ gestation. Sample sizes ranged from 22 to 377 infants. Exposure to human milk included both maternal and donor milk. No study included a full-term comparison group. Main MRI outcome domains were: 1) white matter integrity, assessed with diffusion tensor imaging, resting state functional connectivity, or semi-automated segmentation of white matter abnormality and 2) total and regional brain volumes. Studies revealed that greater exposure to human milk vs. formula was associated with favorable outcomes, including: 1) more mature and connected cerebral white matter with less injury; and 2) larger regional brain volumes, notably in the deep nuclear gray matter, amygdala-hippocampus, and cerebellum. There was no consistent signature effect of human milk exposure, rather the beneficial associations were regional and tissue-specific neuroprotective effects on the areas of known vulnerability in the preterm infant. Evidence to date suggests that human milk may protect the preterm infant from the white matter injury and dysmaturation to which this population is vulnerable. Brain MRI at term equivalent age is emerging as a useful tool to investigate the effects of human milk on the preterm brain. When grounded in neurobiological knowledge about preterm brain injury and development, this approach holds promise for allowing further insight into the mechanisms and pathways underlying beneficial associations of human milk with neurodevelopmental outcomes in this population, and in the investigation of specific milk bioactive components with neuroprotective or neurorestorative potential.
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影响因子：
5.9
作者：
Nieto-Ruiz A;Diéguez E;Sepúlveda-Valbuena N;Herrmann F;Cerdó T;López-Torrecillas F;De-Castellar R;Jiménez J;Pérez-García M;Miranda MT;Catena A;García-Santos JA;Bermúdez MG;Campoy C
通讯作者：
Campoy C
DOI：
10.1093/ajcn/nqab075
发表时间：
2021-05-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Christian P;Smith ER;Lee SE;Vargas AJ;Bremer AA;Raiten DJ
通讯作者：
Raiten DJ
DOI：
10.1139/bcb-2016-0066
发表时间：
2017-03
期刊：
Biochemistry and cell biology = Biochimie et biologie cellulaire
影响因子：
--
作者：
Ochoa TJ;Sizonenko SV
通讯作者：
Sizonenko SV
影响因子：
5.2
作者：
Buffet-Bataillon S;Bellanger A;Boudry G;Gangneux JP;Yverneau M;Beuchée A;Blat S;Le Huërou-Luron I
通讯作者：
Le Huërou-Luron I
母乳喂养改善早产儿功能连接的动态重组：一项颞脑网络研究
影响因子：
3.2
作者：
Niu, Weiming;Xu, Xinfen;Sun, Yu
通讯作者：
Sun, Yu