The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study.
The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study.
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DOI：
10.3390/nu12123825
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发表时间：
2020-12-15
期刊：
影响因子：
5.9
通讯作者：
Campoy C
中科院分区：
文献类型：
--
作者：
Nieto-Ruiz A;Diéguez E;Sepúlveda-Valbuena N;Herrmann F;Cerdó T;López-Torrecillas F;De-Castellar R;Jiménez J;Pérez-García M;Miranda MT;Catena A;García-Santos JA;Bermúdez MG;Campoy C
虽然早期营养会影响大脑发育和心理健康，但补充婴儿配方奶粉对儿童行为的长期影响仍不清楚。我们分析了富含生物活性营养素的婴儿配方奶粉与标准婴儿配方奶粉或母乳喂养相比对2.5岁以下儿童行为的影响。目前的分析涉及70名儿童，他们在出生后的前18个月内喂养标准婴儿配方奶粉（SF，n = 29）或富含生物活性化合物的婴儿配方奶粉（EF，n = 41），33名母乳喂养（BF）的儿童（参照组）参加了COGNIS研究。在18个月和2.5岁时使用儿童行为检查表评估行为问题。使用SPSS进行不同的统计分析。EF儿童2.5岁时的病理性情感问题比SF儿童少。此外，SF儿童更经常被归类为边缘的内化问题比BF儿童。与EF和BF婴儿相比，SF婴儿的外部问题发生率有所增加。较高的母亲智商被发现有有益的影响，内化和总的问题率在他们的后代在18个月的生命;最后，较高的母亲教育水平与较少的ADHD问题的儿童在18个月，以及内化，外化，总和焦虑问题的儿童年龄为2.5岁。我们的分析表明，与标准婴儿配方奶粉喂养的婴儿相比，富含婴儿配方奶粉喂养的婴儿在长达2.5年的时间内似乎表现出更少的行为问题。除早期喂养方式外，母亲的智商和文化程度对儿童行为发育起着关键作用。
Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.
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影响因子：
10.6
作者：
Carlson AL;Xia K;Azcarate-Peril MA;Goldman BD;Ahn M;Styner MA;Thompson AL;Geng X;Gilmore JH;Knickmeyer RC
通讯作者：
Knickmeyer RC
影响因子：
3.6
作者：
Keunen, Kristin;van Elburg, Ruurd M.;van Bel, Frank;Benders, Manon J. N. L.
通讯作者：
Benders, Manon J. N. L.
影响因子：
5.1
作者：
Cerdo, Tomas;Ruiz, Alicia;Campoy, Cristina
通讯作者：
Campoy, Cristina
DOI：
10.1111/j.1365-2850.2011.01743.x
发表时间：
2011-12-01
影响因子：
2.7
作者：
Liu, J.;Chen, X.;Lewis, G.
通讯作者：
Lewis, G.
影响因子：
2.5
作者：
Birch, Eileen E.;Garfield, Sharon;Hoffman, Dennis
通讯作者：
Hoffman, Dennis