Cyto-, myelo- and chemoarchitecture of the prefrontal cortex of the Cebus monkey.
Cyto-, myelo- and chemoarchitecture of the prefrontal cortex of the Cebus monkey.
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DOI：
10.1186/1471-2202-12-6
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发表时间：
2011-01-13
期刊：
影响因子：
2.4
通讯作者：
Casatti CA
中科院分区：
文献类型：
--
作者：
Cruz-Rizzolo RJ;De Lima MA;Ervolino E;de Oliveira JA;Casatti CA
根据几条线索的证据，在灵长类前额叶皮层（PfC）中观察到的巨大扩张伴随着系统发育过程中新皮层区域的出现。因此，灵长类额叶这一区域的结构异质性与人类和非人类灵长类动物中描述的不同行为和认知功能有关。这一证据的很大一部分是使用旧世界的猴子作为实验模型获得的;而新世界的猴子的PfC研究很少。在这项研究中，基于四种不同的结构工具（尼氏染色和髓鞘染色、使用多花紫藤凝集素的组织化学和使用SMI-32抗体的免疫组织化学）分析了五只卷尾猴（Cebus apella）的PfC结构。在CebusPfC内可区分出22个构筑区：外侧PfC内的8v、8d、9d、12 l、45、46 v、46 d、46 vr和46 dr区，眶额皮质内的11 l、11 m、12 o、13 l、13 m、13 i、14 r和14 c区，其中14 r和14 c区位于腹内侧角;内侧PfC的32 r、32 c、25和9 m区，额极的10区。这个数字是显着高于四个cytoarchitectonic领域以前承认在同一物种。然而，这些领域的数量和分布在很大程度上相似，在旧大陆的猴子PfC在最近的研究。本parcellation的Cebus PfC大大修改了该计划最初提出的这个物种，但符合以前的研究旧世界的猴子。因此，据观察，猕猴属和Cebus属的大脑之间的显着解剖相似性可能延伸到架构方面。由于这两个属的猴子在很长一段时间内独立进化，面临不同的环境压力，在两个属的PfC的结构图的相似性是感兴趣的问题。然而，有关Cebus PfC的连接性和功能的其他数据是必要的，以评估潜在的同源性或并行性的可能性。
According to several lines of evidence, the great expansion observed in the primate prefrontal cortex (PfC) was accompanied by the emergence of new cortical areas during phylogenetic development. As a consequence, the structural heterogeneity noted in this region of the primate frontal lobe has been associated with diverse behavioral and cognitive functions described in human and non-human primates. A substantial part of this evidence was obtained using Old World monkeys as experimental model; while the PfC of New World monkeys has been poorly studied. In this study, the architecture of the PfC in five capuchin monkeys (Cebus apella) was analyzed based on four different architectonic tools, Nissl and myelin staining, histochemistry using the lectin Wisteria floribunda agglutinin and immunohistochemistry using SMI-32 antibody. Twenty-two architectonic areas in the Cebus PfC were distinguished: areas 8v, 8d, 9d, 12l, 45, 46v, 46d, 46vr and 46dr in the lateral PfC; areas 11l, 11m, 12o, 13l, 13m, 13i, 14r and 14c in the orbitofrontal cortex, with areas 14r and 14c occupying the ventromedial corner; areas 32r, 32c, 25 and 9m in the medial PfC, and area 10 in the frontal pole. This number is significantly higher than the four cytoarchitectonic areas previously recognized in the same species. However, the number and distribution of these areas in Cebus were to a large extent similar to those described in Old World monkeys PfC in more recent studies. The present parcellation of the Cebus PfC considerably modifies the scheme initially proposed for this species but is in line with previous studies on Old World monkeys. Thus, it was observed that the remarkable anatomical similarity between the brains of genera Macaca and Cebus may extend to architectonic aspects. Since monkeys of both genera evolved independently over a long period of time facing different environmental pressures, the similarities in the architectonic maps of PfC in both genera are issues of interest. However, additional data about the connectivity and function of the Cebus PfC are necessary to evaluate the possibility of potential homologies or parallelisms.
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