Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure.

Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure.
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提高微气泡作为环境压力传感器的检测灵敏度

DOI:
10.3390/s18124083
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发表时间:
2018-11-22
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Yan F
Yan F
中科院分区:
其他
文献类型:
--
作者:
Li F;Li D;Yan F

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微泡被认为是一种有前途的工具,无创估计局部血压。据报道,当浸泡在介质中的环境压力变化从0到180 mmHg时,微泡的次谐波散射振幅下降9到12 dB。然而,压力灵敏度仍需要改进以满足临床诊断要求。在这里,我们研究了声学参数对微泡的压力灵敏度的影响,通过测量市售SonoVue微泡的声衰减和散射特性。我们的结果表明,微泡的一次谐波,次谐波和超谐波振幅在0.225机械指数(MI)时分别降低6.6 dB,10.9 dB和9.3 dB,在0.25 MI时分别降低4.6 dB,19.8 dB和12.3 dB,在0.3 MI时分别降低18.5 dB,17.6 dB和12.6 dB。当环境压力从0增加到180 mmHg时。我们的研究结果表明,适度的MI(0.25-0.4)激发微泡可以显着提高其检测环境压力的灵敏度。
Microbubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure sensitivity still needs to be improved to satisfy clinical diagnostic requirements. Here, we investigated the effects of acoustic parameters on the pressure sensitivity of microbubbles through measuring the acoustic attenuation and scattering properties of commercially available SonoVue microbubbles. Our results showed that the first harmonic, subharmonic, and ultraharmonic amplitudes of microbubbles were reduced by 6.6 dB, 10.9 dB, and 9.3 dB at 0.225 mechanical index (MI), 4.6 dB, 19.8 dB, and 12.3 dB at 0.25 MI, and 18.5 dB, 17.6 dB, and 12.6 dB at 0.3 MI, respectively, when the ambient pressure increased from 0 to 180 mmHg. Our finding revealed that a moderate MI (0.25–0.4) exciting microbubbles could significantly improve their sensitivities to detect ambient pressure.
DOI: 10.1016/0301-5629(93)90100-3
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