Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.
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DOI：
10.3389/fcvm.2018.00114
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发表时间：
2018
影响因子：
3.6
通讯作者：
Kuppusamy P
中科院分区：
文献类型：
--
作者：
Prabhat AM;Kuppusamy ML;Naidu SK;Meduru S;Reddy PT;Dominic A;Khan M;Rivera BK;Kuppusamy P
心肌梗死（MI）通常由于急性缺血后再流而发生，与心肌细胞的不可逆损失（死亡）相关。如果不及时治疗，MI将导致存活心肌细胞的进行性丧失、心脏功能恶化和充血性心力衰竭。虽然辅助供氧治疗长期以来一直用于治疗急性心肌梗死，但观察到的有益效果尚未有明确的科学依据。此外，对于有效治疗，补充氧合的给药量或给药持续时间没有依据。本研究的目的是确定一个最佳的氧合协议，可以在临床上适用于治疗急性心肌梗死。使用EPR血氧测定法，我们研究了暴露于通过吸入21-100%氧气持续短暂时间（15-90分钟），每天持续5天，使用急性MI大鼠模型的补充氧循环（OxCy）的影响。心肌氧分压（pO 2），心脏功能和促生存/凋亡信号分子被用作治疗结果的标志物。OxCy可显著缩小梗死面积并改善心功能。发现在常压条件下用95%氧气+5%CO2进行30分钟OxCy的最佳条件对心脏保护有效。
Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO2), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO2 under normobaric conditions was found to be effective for cardioprotection.
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影响因子：
105.7
作者：
KENMURE, ACF;MURDOCH, WR;CAMERON, AJ
通讯作者：
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