Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.
Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.
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DOI：
10.3389/fnsyn.2021.684141
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发表时间：
2021
影响因子：
3.7
通讯作者：
Galazyuk AV
中科院分区：
文献类型：
--
作者：
Hsiao CJ;Galazyuk AV
声音暴露引起的神经活动亢进往往与听力过敏症和/或耳鸣的发生有关。在实验动物中，多动症通常是由单侧声音暴露引起的，以保护一只耳朵，以便进一步测试听力表现。听觉系统中的大多数上升纤维穿过上橄榄复合体，然后对侧上升。因此，单侧暴露应该主要影响听觉脑干上方的对侧。另一方面，众所周知，相当数量的神经元在听觉通路的每个水平都有交叉纤维，这可能会将单侧暴露的影响扩散到同侧。在这里，我们证明了单侧声音暴露会导致小鼠对侧和同侧下丘的过度活动。我们发现，与未暴露的小鼠相比，自发放电率和爆发活动都显著增加。特征频率在暴露中心频率或以上的神经元表现出最大的增加。令人惊讶的是，这种增加在同侧下丘更为明显。这项研究强调了在未来利用单侧声音暴露的研究中同时考虑自发性和对侧效应的重要性。
Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further testing of hearing performance. Most ascending fibers in the auditory system cross into the superior olivary complex and then ascend contralaterally. Therefore, unilateral exposure should be expected to mostly affect the contralateral side above the auditory brain stem. On the other hand, it is well known that a significant number of neurons have crossing fibers at every level of the auditory pathway, which may spread the effect of unilateral exposure onto the ipsilateral side. Here we demonstrate that unilateral sound exposure causes development of hyperactivity in both the contra and ipsilateral inferior colliculus in mice. We found that both the spontaneous firing rate and bursting activity were increased significantly compared to unexposed mice. The neurons with characteristic frequencies at or above the center frequency of exposure showed the greatest increase. Surprisingly, this increase was more pronounced in the ipsilateral inferior colliculus. This study highlights the importance of considering both ipsi- and contralateral effects in future studies utilizing unilateral sound exposure.
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影响因子：
2.8
作者：
Manzoor NF;Gao Y;Licari F;Kaltenbach JA
通讯作者：
Kaltenbach JA
DOI：
10.1111/ejn.12580
发表时间：
2014-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Coomber B;Berger JI;Kowalkowski VL;Shackleton TM;Palmer AR;Wallace MN
通讯作者：
Wallace MN
影响因子：
2.8
作者：
Brozoski, TJ;Bauer, CA
通讯作者：
Bauer, CA
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
影响因子：
3.4
作者：
Galazyuk A;Hébert S
通讯作者：
Hébert S