Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study.
Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study.
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DOI：
10.1136/bmj.j4273
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发表时间：
2017-10-04
期刊：
影响因子：
--
通讯作者：
Lee BK
中科院分区：
文献类型：
--
作者：
DeVilbiss EA;Magnusson C;Gardner RM;Rai D;Newschaffer CJ;Lyall K;Dalman C;Lee BK
确定怀孕期间补充营养是否与降低后代患有或不患有智力障碍的自闭症谱系障碍 (ASD) 风险相关。使用多变量逻辑回归、兄弟姐妹对照和倾向评分匹配的观察性前瞻性队列研究。瑞典斯德哥尔摩县。通过人口登记册确定了 273 107 对母子。研究样本仅限于 2011 年 12 月 31 日随访结束时年龄为 4 至 15 岁、出生于 1996 年至 2007 年之间的儿童。在第一次产前检查时报告了复合维生素、铁和叶酸补充剂的使用情况。根据截至 2011 年 12 月 31 日的登记数据确定儿童患有或不患有智力障碍的自闭症谱系障碍 (ASD) 的诊断。母亲服用多种维生素组中，患有智力障碍的自闭症谱系障碍 (ASD) 患病率为 0.26%（61-934 例中的 158 例），而在未使用营养补充剂的组中，该患病率为 0.48%（90-480 例中的 430 例）。与不使用多种维生素、铁和叶酸的母亲相比，母亲使用多种维生素并补充或不补充铁或叶酸，或两者兼而有之，与儿童患有自闭症谱系障碍和智力障碍的几率较低相关（比值比 0.69，95% 置信区间 0.57 至 0.84）。在倾向评分匹配（0.68、0.54 至 0.86）和兄弟姐妹对照（0.77、0.52 至 1.15）匹配分析中也发现了类似的估计，尽管后者关联的置信区间包括 1.0，因此不具有统计显着性。没有一致的证据表明铁或叶酸的使用与 ASD 患病率呈负相关。母亲在怀孕期间补充多种维生素可能与后代患有自闭症谱系障碍（ASD）和智力障碍呈负相关。建议进一步检查孕产妇营养及其在自闭症病因中的作用。
To determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) with and without intellectual disability in offspring. Observational prospective cohort study using multivariable logistic regression, sibling controls, and propensity score matching. Stockholm County, Sweden. 273 107 mother-child pairs identified through population registers. The study sample was restricted to children who were aged 4 to 15 years by the end of follow-up on 31 December 2011 and were born between 1996 and 2007. Multivitamin, iron, and folic acid supplement use was reported at the first antenatal visit. Diagnosis of ASD with and without intellectual disability in children determined from register data up to 31 December 2011. Prevalence of ASD with intellectual disability was 0.26% (158 cases in 61 934) in the maternal multivitamin use group and 0.48% (430 cases in 90 480) in the no nutritional supplementation use group. Maternal multivitamin use with or without additional iron or folic acid, or both was associated with lower odds of ASD with intellectual disability in the child compared with mothers who did not use multivitamins, iron, and folic acid (odds ratio 0.69, 95% confidence interval 0.57 to 0.84). Similar estimates were found in propensity score matched (0.68, 0.54 to 0.86) and sibling control (0.77, 0.52 to 1.15) matched analyses, though the confidence interval for the latter association included 1.0 and was therefore not statistically significant. There was no consistent evidence that either iron or folic acid use were inversely associated with ASD prevalence. Maternal multivitamin supplementation during pregnancy may be inversely associated with ASD with intellectual disability in offspring. Further scrutiny of maternal nutrition and its role in the cause of autism is recommended.
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影响因子：
20.8
作者：
Lyall K;Croen L;Daniels J;Fallin MD;Ladd-Acosta C;Lee BK;Park BY;Snyder NW;Schendel D;Volk H;Windham GC;Newschaffer C
通讯作者：
Newschaffer C
影响因子：
5.6
作者：
Leonard, Helen;De Klerk, Nick;Bower, Carol
通讯作者：
Bower, Carol
影响因子：
3.9
作者：
Braun, Joseph M.;Froehlich, Tanya;Kalkbrenner, Amy;Pfeiffer, Christine M.;Fazili, Zia;Yolton, Kimberly;Lanphear, Bruce P.
通讯作者：
Lanphear, Bruce P.
DOI：
10.1177/140349489001800209
发表时间：
1990-01-01
期刊：
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE
影响因子：
--
作者：
CNATTINGIUS, S;ERICSON, A;KALLEN, B
通讯作者：
KALLEN, B
影响因子：
3.2
作者：
Mikkelsen, Tina B.;Osler, Merete;Olsen, Sjurdur F.
通讯作者：
Olsen, Sjurdur F.