A fast UV-curable PU-PAAm hydrogel with mechanical flexibility and self-adhesion for wound healing.
A fast UV-curable PU-PAAm hydrogel with mechanical flexibility and self-adhesion for wound healing.
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一种快速紫外线固化 PU-PAAm 水凝胶，具有机械灵活性和自粘性，可促进伤口愈合
作者：
水凝胶表现出有利于伤口愈合的优越特性，并已广泛用于临床伤口敷料应用。然而，商业水凝胶敷料往往缺乏柔韧性/粘附性，并且不符合复杂伤口和/或关节附近伤口的不规则皮肤表面。因此，伤口很可能暴露于潜在的细菌入侵。在此，我们设计并开发了一种机械柔性和自粘聚氨酯-聚丙烯酰胺（PU-PAAm）水凝胶，用于伤口愈合应用。该新型水性乳液在紫外线照射下可在90 s内固化。PU-PAAm水凝胶中的PU成分起到了“桥接”作用，加速了互穿聚合物网络（IPN）的形成，IPN由物理交联的PU网络被化学交联的PAAm网络所包围。独特的IPN结构赋予水凝胶优越的拉伸性和延展性。水凝胶与皮肤之间的氢键形成和静电相互作用确保了很强的附着力，在去除敷料后不会对皮肤造成刺激。动物实验进一步证实了PU-PAAm水凝胶具有显著的皮肤再生能力。这项工作表明，我们的新型水凝胶在治疗复杂或具有挑战性的伤口如烧伤和慢性伤口方面具有很好的前景。
Hydrogels demonstrate superior properties that favor wound healing and have been widely used in clinical settings for wound dressing applications. However, commercial hydrogel dressings often lack flexibility/adhesiveness, and do not conform well to the irregular skin surfaces of complex wounds and/or wounds near joints. As a result, the wound is likely to be exposed to potential bacterial invasion. Herein, we designed and developed a mechanically flexible and self-adhesive polyurethane-poly(acrylamide) (PU-PAAm) hydrogel for wound healing applications. The hydrogel can be cured from a novel waterborne emulsion within 90 s under UV irradiation. The PU component within the PU-PAAm hydrogel plays a “bridging” role that accelerates the formation of an interpenetrating polymer network (IPN), which consists of a physically crosslinked PU network trapped within a chemically crosslinked PAAm network. The unique IPN structure endowes the hydrogel with superior stretchability and ductility. The hydrogen bonding formation and electrostatic interaction between the hydrogel and skin ensure strong adhesion without causing irritation to skin upon dressing removal. Animal studies further confirmed the PU-PAAm hydrogel's remarkable skin regeneration capability. This work shows our new hydrogel holds a promising prospect for treatment of complicated or challenging wounds such as burns and chronic wounds.
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基于银木质素纳米颗粒触发动态氧化还原儿茶酚化学的植物启发粘合剂和坚韧水凝胶
影响因子：
16.6
作者：
Gan, Donglin;Xing, Wensi;Lu, Xiong
通讯作者：
Lu, Xiong
影响因子：
2.5
作者：
Cui, Jiaxi;Iturri, Jagoba;del Campo, Arynzazu
通讯作者：
del Campo, Arynzazu
影响因子：
14
作者：
Nguyen, KT;West, JL
通讯作者：
West, JL
DOI：
10.1016/s0964-8305(02)00051-3
发表时间：
2002-01-01
影响因子：
4.8
作者：
Howard, GT
通讯作者：
Howard, GT
DOI：
10.1097/00005373-197909000-00001
发表时间：
1979-01-01
影响因子：
--
作者：
BAKER, CC;MILLER, CL;TRUNKEY, DD
通讯作者：
TRUNKEY, DD