Association between transthyretin concentrations and gestational diabetes mellitus in Chinese women
Association between transthyretin concentrations and gestational diabetes mellitus in Chinese women
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中国女性转甲状腺素蛋白浓度与妊娠期糖尿病的关系
DOI：
10.1007/s00404-020-05599-y
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发表时间：
2020-05
影响因子：
2.6
通讯作者：
Danqing Chen
中科院分区：
文献类型：
--
作者：
Mengting Liu;Yanmin Chen;Danqing Chen
背景甲状腺素运载蛋白（transthyretin，TTR）被认为与人类胰岛素抵抗有关。本研究旨在探讨妊娠期糖尿病（GDM）患者TTR水平及其与糖代谢的关系。结果妊娠期糖尿病组血清TTR水平明显高于对照组（P < 0. 05），且TTR与糖、脂代谢的相关性显著高于对照组（P < 0. 05（中位数，93.44 [四分位距，73.81，117.79] μg/ml vs. 80.83 [74.19，89.38] μg/ml;P= 0.006）。GDM受试者的RBP 4/TTR比值低于对照受试者（中位数，517.57 [四分位距，348.38，685.27] vs. 602.56 [460.28，730.62];P= 0.02）。血清TTR水平与新生儿体重（r= 0.223，P = 0.028）、胰岛素抵抗（r= 0.246，P = 0.015）和空腹血糖（r= 0.363，P < 0.001）呈正相关。多元逐步回归分析显示，FBG（标准化β = 0.27，P = 0.004）和新生儿体重（标准化β = 0.345，P < 0.001）是血清TTR浓度的独立预测因素。此外，FBG（标准化β =-0.306，P = 0.002）和TG（β = 0.219，P = 0.025）与RBP 4/TTR比值独立相关。结论GDM患者血清TTR浓度显著高于非GDM患者，提示TTR水平升高可能在GDM的发病机制中起一定作用。TTR与FBG和新生儿体重独立相关，FBG和TG是RBP 4/TTR比值的独立预测因子。此外，血清TTR水平和RBP 4/TTR比值被认为是胰岛素抵抗和GDM的有价值的标志物。
BackgroundTransthyretin (TTR) is considered to be associated with insulin resistance in humans. This study aimed to investigate TTR level in gestational diabetes mellitus (GDM) and its association with glucose metabolism.MethodsFifty pregnant women with GDM and 47 pregnant women with normal glucose tolerance matched for body mass index and age were enrolled in this study. Their blood samples were collected to detect TTR, retinol-binding protein 4 (RBP4), and their association with glucose and lipid metabolism.ResultsSerum TTR levels in the GDM group were significantly higher than those in the control group (median, 93.44 [interquartile range, 73.81, 117.79] μg/ml vs. 80.83 [74.19, 89.38] μg/ml;P= 0.006). GDM subjects had a lower RBP4/TTR ratio than the control subjects (median, 517.57 [interquartile range, 348.38, 685.27] vs. 602.56 [460.28, 730.62];P= 0.02). The serum TTR concentrations were positively associated with neonatal weight (r= 0.223,P= 0.028), homeostatic model assessment of insulin resistance (r= 0.246,P= 0.015), and fasting blood glucose (FBG) (r= 0.363,P< 0.001). In stepwise multivariate linear regression analysis, FBG (standardized beta = 0.27,P= 0.004) and neonatal weight (standardized beta = 0.345,P< 0.001) were independent predictors of serum TTR concentrations. Additionally, FBG (standardized beta = − 0.306,P= 0.002) and triglyceride (TG) (beta = 0.219,P= 0.025) were independently associated with RBP4/TTR ratio.ConclusionsSerum TTR concentrations were significantly higher in women with GDM than that in women without GDM, suggesting that elevated TTR level may play a role in the pathogenesis of GDM. Meanwhile, TTR was positively and independently associated with FBG and neonatal weight, while FBG and TG were independent predictors of RBP4/TTR ratio. Moreover, serum TTR levels and RBP4/TTR ratio were considered valuable markers of insulin resistance and GDM.
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DOI：
10.1111/j.1651-2227.1988.tb10739.x
发表时间：
1988-09
期刊：
Acta Pædiatrica
影响因子：
--
作者：
A. M. Kobbah;K. Hellsing;T. Tuvemo
通讯作者：
A. M. Kobbah;K. Hellsing;T. Tuvemo
影响因子：
5.4
作者：
E. Diamanti-Kandarakis;S. Livadas;S. A. Kandarakis;I. Papassotiriou;A. Margeli
通讯作者：
E. Diamanti-Kandarakis;S. Livadas;S. A. Kandarakis;I. Papassotiriou;A. Margeli
RBP4在妊娠期糖尿病患者中的意义：中国汉族女性的病例对照研究
影响因子：
2
作者：
Liang Zhaoxia;Du Mengkai;Chen Danqing
通讯作者：
Chen Danqing
影响因子：
29
作者：
Kloeting, Nora;Graham, Timothy E.;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.
影响因子：
6.5
作者：
Liz, Marcia Almeida;Gomes, Claudio M.;Sousa, Monica Mendes
通讯作者：
Sousa, Monica Mendes