Alterations of bacterial communities of vocal cord mucous membrane increases the risk for glottic laryngeal squamous cell carcinoma.
Alterations of bacterial communities of vocal cord mucous membrane increases the risk for glottic laryngeal squamous cell carcinoma.
复制标题
声带粘膜细菌群落的改变会增加声门喉鳞状细胞癌的风险
DOI：
10.7150/jca.54221
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发表时间：
2021
影响因子：
3.9
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Dong Z;Zhang C;Zhao Q;Huangfu H;Xue X;Wen S;Wu Y;Gao W;Wang B
细菌是维持人体健康的重要因素之一，它们与某些肿瘤的关系已经得到了很好的证实。然而，细菌定植在声带和声门喉部鳞状细胞癌（GLSCC）之间的关系尚不清楚。在这里，我们研究了声带粘膜的细菌群落是否在GLSCC的发展中起作用。我们收集了19例GLSCC患者的肿瘤组织和正常邻近组织（NAT）样本，并使用16S rRNA高通量焦磷酸测序技术将21例声带息肉的细菌群落与对照样本（control）进行了比较。在声带粘膜中发现41门，93纲，188目，373科，829属。NAT样品中细菌群落的α‐多样性高于肿瘤样品。线性判别分析结合效应大小测量（LEfSe）结果显示，在肿瘤样品中，梭杆菌门、梭杆菌纲、梭杆菌目、梭杆菌科、梭杆菌属、异普雷沃菌属和普雷沃菌属等7个菌群均显著富集。然而，来自厚壁菌门的细菌在声带息肉组织中富集最为显著。这些发现提示GLSCC患者声带粘膜细菌群落结构的改变，7组细菌与GLSCC有关，表明细菌群落的不平衡增加了GLSCC发展的风险。
Bacteria are among the important factors that play a role in the balance of human health, and their relationship with some tumors has been well established. However, the association between bacteria colonizing the vocal cords and glottic laryngeal squamous cell carcinoma (GLSCC) remains unclear. Here, we investigated whether bacterial communities of the vocal cord mucous membrane play a role in the development of GLSCC. We collected tumor tissue and normal adjacent tissue (NAT) samples from 19 GLSCC patients, and the bacterial communities were compared with control samples (control) from 21 vocal cord polyps using 16S rRNA high-throughput pyrosequencing. We detected 41 phyla, 93 classes, 188 orders, 373 families, and 829 genera in the vocal cord mucous membrane. A comparison of the bacterial communities in the NAT samples showed higher α‐diversity than in the tumor samples. In the tumor samples, seven groups of bacteria, i.e., the phylum Fusobacteria, the class Fusobacteriia, the order Fusobacteriales, the family Fusobacteriaceae, and the genera Fusobacterium, Alloprevotella, and Prevotella, were significantly enriched, as revealed by linear discriminant analysis coupled with effect size measurements (LEfSe). However, bacteria from the phylum Firmicutes were most significantly enriched in the vocal cord polyp tissues. These findings suggest alterations in the bacterial community structure of the vocal cord mucous membrane of GLSCC patients and that seven groups of bacteria are related to GLSCC, indicating that imbalances in bacterial communities increase the risk for the development of GLSCC.
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ACE2将氨基酸营养不良与微生物生态学和肠炎联系起来。
影响因子：
64.8
作者：
Hashimoto T;Perlot T;Rehman A;Trichereau J;Ishiguro H;Paolino M;Sigl V;Hanada T;Hanada R;Lipinski S;Wild B;Camargo SM;Singer D;Richter A;Kuba K;Fukamizu A;Schreiber S;Clevers H;Verrey F;Rosenstiel P;Penninger JM
通讯作者：
Penninger JM
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
5.7
作者：
Hu, Yuan-Liang;Pang, Wei;Zhang, Chao-Jun
通讯作者：
Zhang, Chao-Jun
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
15.5
作者：
Benitez AJ;Hoffmann C;Muir AB;Dods KK;Spergel JM;Bushman FD;Wang ML
通讯作者：
Wang ML