An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.
An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.
复制标题
对两个岛屿组的分析，作为用于疟疾控制的转基因蚊子试验的潜在部位。
DOI：
10.1111/eva.12056
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发表时间：
2013-06
影响因子：
4.1
通讯作者：
Lanzaro GC
中科院分区：
文献类型：
--
作者：
Marsden CD;Cornel A;Lee Y;Sanford MR;Norris LC;Goodell PB;Nieman CC;Han S;Rodrigues A;Denis J;Ouledi A;Lanzaro GC
在生产用于病媒控制的转基因蚊子方面已经取得了相当大的技术进步。相比之下，对转基因蚊子的现场评估进展较少，这对于评估基因改造的成功和相关危害至关重要。大洋岛屿被认为是此类试验的潜在最佳地点。然而，需要进行群体遗传学研究来验证隔离。在这里，我们使用一组遗传标记来评估非洲疟疾媒介冈比亚按蚊 s.s. 的两个大洋岛屿种群的遗传隔离证据。我们没有发现比热戈斯群岛和几内亚比绍大陆之间存在隔离的证据，尽管两者之间的距离超出了该类群已知的扩散能力。相反，科摩罗群岛似乎在基因上与东非大陆隔离，因此是一个值得进一步调查和实地试验的地点。根据对科摩罗群岛内部和之间的基因流动的评估，发现大科摩罗岛与邻近岛屿在基因上是隔离的，并且还表现出当地的人口结构，这表明它可能是最适合试验现有基因改造技术的地点。
Considerable technological advances have been made towards the generation of genetically modified mosquitoes for vector control. In contrast, less progress has been made towards field evaluations of transformed mosquitoes which are critical for evaluating the success of, and hazards associated with, genetic modification. Oceanic islands have been highlighted as potentially the best locations for such trials. However, population genetic studies are necessary to verify isolation. Here, we used a panel of genetic markers to assess for evidence of genetic isolation of two oceanic island populations of the African malaria vector, Anopheles gambiae s.s. We found no evidence of isolation between the Bijagós archipelago and mainland Guinea-Bissau, despite separation by distances beyond the known dispersal capabilities of this taxon. Conversely, the Comoros Islands appear to be genetically isolated from the East African mainland, and thus represent a location worthy of further investigation for field trials. Based on assessments of gene flow within and between the Comoros islands, the island of Grande Comore was found to be genetically isolated from adjacent islands and also exhibited local population structure, indicating that it may be the most suitable site for trials with existing genetic modification technologies.
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影响因子：
2.6
作者：
Fanello, C;Petrarca, V;Coluzzi, M
通讯作者：
Coluzzi, M
影响因子：
3.8
作者：
Donnelly, MJ;Pinto, J;Lehmann, T
通讯作者：
Lehmann, T
DOI：
10.4269/ajtmh.2003.69.200
发表时间：
2003-08-01
影响因子：
3.3
作者：
Cohuet, A;Simard, F;Fontenille, D
通讯作者：
Fontenille, D
影响因子：
3
作者：
Chen, H;Minakawa, N;Yan, GY
通讯作者：
Yan, GY
DOI：
10.1186/jbiol143
发表时间：
2009-05-01
期刊：
Journal of Biology (London)
影响因子：
--
作者：
Alphey, Luke
通讯作者：
Alphey, Luke