Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures.
Cartilage and meniscal T2 relaxation time as non-invasive biomarker for knee osteoarthritis and cartilage repair procedures.
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DOI：
10.1016/j.joca.2013.07.012
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发表时间：
2013-10
影响因子：
7
通讯作者：
Bauer, J. S.
中科院分区：
文献类型：
--
作者：
Baum, T.;Joseph, G. B.;Karampinos, D. C.;Jungmann, P. M.;Link, T. M.;Bauer, J. S.
这项工作的目的是回顾目前关于软骨和半月板T2松弛时间的文献。在PubMed中进行电子搜索，以确定T2松弛时间测量作为膝骨性关节炎(OA)和软骨修复手术的非侵入性生物标记物的相关研究。最初的骨关节炎改变包括蛋白多糖丢失，胶原网络恶化，关节软骨和半月板内水分增加。T2弛豫时间的测量受到这些病理生理过程的影响。结果显示，关节软骨和半月板T2松弛时间值分别比无放射性骨性关节炎和膝关节局灶性病变的受试者显著增加。有骨性关节炎危险因素如超重/肥胖的受试者的软骨T2值显著高于正常对照组。有膝关节疼痛的受试者与无膝关节疼痛的受试者相比，软骨和半月板T2松弛时间延长。基线时软骨T2的增加预示着3年后软骨、半月板和骨髓的形态退化。此外，软骨修复组织可以通过T2标测进行非侵入性评估。据报道，T2测量的重复性误差小于健康和病变软骨的T2差值，这表明T2松弛时间可能是一个可靠的生物标志物。软骨和半月板T2图可作为膝关节骨关节炎早期诊断和监测疗效的无创性生物标志物。
The purpose of this work was to review the current literature on cartilage and meniscal T2 relaxation time. Electronic searches in PubMed were performed to identify relevant studies about T2 relaxation time measurements as non-invasive biomarker for knee osteoarthritis (OA) and cartilage repair procedures. Initial osteoarthritic changes include proteoglycan loss, deterioration of the collagen network, and increased water content within the articular cartilage and menisci. T2 relaxation time measurements are affected by these pathophysiological processes. It was demonstrated that cartilage and meniscal T2 relaxation time values were significantly increased in subjects with compared to those without radiographic OA and focal knee lesions, respectively. Subjects with OA risk factors such as overweight/obesity showed significantly greater cartilage T2 values than normal controls. Elevated cartilage and meniscal T2 relaxation times were found in subjects with vs without knee pain. Increased cartilage T2 at baseline predicted morphologic degeneration in the cartilage, meniscus, and bone marrow over 3 years. Furthermore, cartilage repair tissue could be non-invasively assessed by using T2 mapping. Reproducibility errors for T2 measurements were reported to be smaller than the T2 differences in healthy and diseased cartilage indicating that T2 relaxation time may be a reliable discriminatory biomarker. Cartilage and meniscal T2 mapping may be suitable as non-invasive biomarker to diagnose early stages of knee OA and to monitor therapy of OA.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
7
作者：
Blumenkrantz, G.;Stahl, R.;Majumdar, S.
通讯作者：
Majumdar, S.
DOI：
10.2214/ajr.08.2256
发表时间：
2009-11
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Friedrich KM;Shepard T;de Oliveira VS;Wang L;Babb JS;Schweitzer M;Regatte R
通讯作者：
Regatte R
影响因子：
7
作者：
Apprich, S.;Welsch, G. H.;Trattnig, S.
通讯作者：
Trattnig, S.
影响因子：
7
作者：
Bae, K. T.;Shim, H.;Kwoh, C. K.
通讯作者：
Kwoh, C. K.