Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial.
Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial.
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带单毛刷的新型非处方牙周膏涂药器对支持性牙周治疗阶段龈沟液中细胞因子水平的影响：一项随机双盲临床试验。
DOI：
10.1111/jre.12311
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发表时间：
2016
影响因子：
3.5
通讯作者：
Takashiba S.
中科院分区：
文献类型：
--
作者：
Takeuchi-Hatanaka K;Yasuda T;Naruishi K;Katsuragi-Fuke K;Inubushi J;Ootsuki H;Maeda H;Takashiba S.
背景与目的研究一种非处方药(OTC)的生物化学效应，该非处方药由含有杀菌剂氯化十六烷基吡啶、抗炎药物甘草酸二钾和促进细胞增殖和创面愈合的尿囊素组成的单丛刷子组成，用于难以刷牙的部位。材料和方法对61例处于支持牙周治疗阶段的慢性牙周炎患者进行随机双盲研究(试验组：n=27；安慰剂组：n=28；辍学：n=6)。OTC药物自我应用，每天两次，持续12周，探测袋深4-6 mm的两个磨牙。分别于治疗前和治疗12wk后，采用悬浮法检测牙周液中8种细胞因子和趋化因子(IL-1β、IL-1ra、IL-4、IL-6、IL-8、IL-10、单核细胞趋化蛋白-1和肿瘤坏死因子-α)的生化指标。结果试验组IL-1β、IL-6、IL-8和肿瘤坏死因子-α水平明显低于安慰剂组。在安慰剂组中，当基线探诊深度为4 mm时，IL-1β升高，尤其是第二磨牙，当基线深度为5~6 mm时，IL-1 PPD升高幅度最大。在试验组中，基线探查时有分叉受累且出血少的患者，IL-1β显著降低。两组患者IL-1β、IL-6、α水平呈正相关。结论该非处方药对稳定期慢性牙周炎患者在支持牙周治疗阶段有较好的生化疗效。
Background and ObjectiveThe biochemical effects of an over‐the‐counter (OTC) medication were studied, which consists of a single‐tuft brush containing cetylpyridinium chloride as a bactericidal agent, dipotassium glycyrrhizate as an anti‐inflammatory drug and allantoin as a promoter of cell proliferation and wound healing, for delivery to hardly brushed sites.Material and MethodsThis randomized controlled double‐blind study was performed in 61 subjects with chronic periodontitis in supportive periodontal therapy phase (test group:n= 27; placebo group:n= 28; dropout:n= 6). The OTC medication was self‐applied twice a day for 12 wk to two molars with probing pocket depths of 4–6 mm. Biochemical indicators were evaluated at baseline and 12 wk using the suspension array system for eight cytokines and chemokines (interleukin [IL]‐1β, IL‐1ra, IL‐4, IL‐6, IL‐8, IL‐10, monocyte chemoattractant protein‐1 and tumor necrosis factor [TNF]‐α) in gingival crevicular fluid.ResultsThe levels of IL‐1β, IL‐6, IL‐8 and TNF‐α remained significantly lower in the test group compared to the placebo group. In the placebo group, when the probing pocket depth at baseline was 4 mm, IL‐1β increased, particularly in the second molar tooth, and the greatest increase was seen when PPD at baseline was 5–6 mm. In the test group, IL‐1β decreased markedly in cases with furcation involvement and low bleeding on probing at baseline. In both groups, IL‐1β, IL‐6 and TNF‐α were closely correlated with each other.ConclusionThis OTC medication is biochemically effective for steady chronic periodontitis in the supportive periodontal therapy phase.
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影响因子：
6.7
作者：
Ximénez-Fyvie, LA;Haffajee, AD;Socransky, SS
通讯作者：
Socransky, SS
DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
K. Hatanaka;Kyoko Fuke;K. Seno;T. Tomiyama;K. Iwaki;T. Kunikata;N. Masaki;S. Fukuda;H. Maeda;H. Arai;S. Takashiba
通讯作者：
S. Takashiba
齿垢密螺旋体和牙龈卟啉单胞菌作为牙周治疗后的预后标志物。
影响因子：
4.3
作者：
Lloyd G. Simonson;Peter J. Robinson;Rory J. Pranger;M. Cohen;Harold E. Morton
通讯作者：
Harold E. Morton
影响因子：
2
作者：
LOE, HARALD;SILNESS, JOHN
通讯作者：
SILNESS, JOHN
影响因子：
4.3
作者：
Offenbacher, S.;Barros, S. P.;Beck, J. D.
通讯作者：
Beck, J. D.