Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.
Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.
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DOI：
10.1037/a0033945
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发表时间：
2013-10
影响因子：
1.9
通讯作者：
Baum, Michael J.
中科院分区：
文献类型：
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作者：
Korzan, Wayne J.;Freamat, Mihael;Johnson, Adam G.;Cherry, James A.;Baum, Michael J.
长期以来的一种观点认为，雄性小鼠对雌性体味的兴趣反映了在犁鼻器（VNO）检测到雌性体味并通过辅助嗅觉系统进行处理后，雄性大脑中奖励回路的激活。我们发现，成年、性幼稚的雄性小鼠在反复用鼻子接受发情雌性尿液并被放置在最初不喜欢性的房间里，并且地板上有肮脏的发情床上用品后，获得了条件性位置偏好（CPP）。在将小鼠放入具有干净垫料的非首选室之前，在鼻子上接受盐水的对照小鼠没有获得 CPP。使用发情雌性气味作为奖励的 CPP 的稳健获取在不同的小鼠组中持续存在，其中 VNO 辅助嗅觉功能因副嗅球 (AOB) 的双侧损伤而受到干扰，或者主要嗅觉功能因主嗅上皮 (MOE) 的硫酸锌损伤而受到干扰。相比之下，接受 AOB 和 MOE 联合损伤的男性的发情气味没有获得 CPP。即使在没有交配经验的情况下，主嗅觉系统或辅助嗅觉系统都足以调节雄性小鼠发情雌性气味的奖励作用。主嗅觉系统是对参与动机行为的化学信号做出反应的电路的一部分，对于缺乏功能性辅助嗅觉系统的人类来说，这一作用可能特别重要。
A long-held view has been that interest of male mice in female body odors reflects an activation of reward circuits in the male brain following their detection by the vomeronasal organ (VNO) and processing via the accessory olfactory system. We found that adult, sexually naïve male mice acquired a conditioned place preference (CPP) after repeatedly receiving estrous female urine on the nose and being placed in an initially non-preferred chamber with soiled estrous bedding on the floor. CPP was not acquired in control mice that received saline on the nose before being placed in a non-preferred chamber with clean bedding. Robust acquisition of a CPP using estrous female odors as the reward persisted in separate groups of mice in which VNO-accessory olfactory function was disrupted by bilateral lesioning of the accessory olfactory bulb (AOB) or in which main olfactory function was disrupted by zinc sulfate lesions of the main olfactory epithelium (MOE). By contrast, no CPP was acquired for estrous odors in males that received combined AOB and MOE lesions. Either the main or the accessory olfactory system suffices to mediate the rewarding effects of estrous female odors in the male mouse, even in the absence of prior mating experience. The main olfactory system is part of the circuitry that responds to chemosignals involved in motivated behavior, a role that may be particularly important for humans which lack a functional accessory olfactory system.
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影响因子：
3.3
作者：
Kang, N.;McCarthy, E. A.;Cherry, J. A.;Baum, M. J.
通讯作者：
Baum, M. J.
影响因子：
2.9
作者：
LEHMAN, MN;WINANS, SS
通讯作者：
WINANS, SS
DOI：
10.1523/jneurosci.1311-09.2009
发表时间：
2009-06-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Martel KL;Baum MJ
通讯作者：
Baum MJ
影响因子：
2.9
作者：
Novejarque, Amparo;Gutierrez-Castellanos, Nicolas;Martinez-Garcia, Fernando
通讯作者：
Martinez-Garcia, Fernando
影响因子：
64.8
作者：
通讯作者：
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