Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus trip.
Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus trip.
复制标题
DOI：
10.1289/ehp.9386
复制
发表时间：
2007-04
影响因子：
10.4
通讯作者：
Suh H
中科院分区：
文献类型：
--
作者：
Adar SD;Adamkiewicz G;Gold DR;Schwartz J;Coull BA;Suh H
空气中的颗粒物与肺部氧化应激和炎症有关。由于这些影响可能对交通相关颗粒物特别大，我们在一项对44名老年人的研究中研究了颗粒物暴露与呼出一氧化氮（FENO）之间的关系，该研究涉及多次乘坐柴油公交车。使用混合模型控制受试者、日、旅行、维生素、收集装置、霉菌、花粉、室内空气一氧化氮、表观温度和分析时间，对旅行前后收集的FENO样品进行回归分析。虽然环境浓度是在一个固定地点收集的，但连续的群体一级个人样本表征了整个设施和旅行期间的微环境暴露。在出行前的样本中，微环境和环境中的细颗粒物暴露与FENO呈正相关。例如，每日微环境PM2.5浓度四分位数增加4 μg/m3与FENO增加13%（95%置信区间（CI），2-24%）相关。然而，在旅行后，FENO浓度主要与微环境暴露相关，全天测量的浓度具有显著的相关性。与旅行期间暴露的相关性也很强，具有统计学显著性，PM2.5每四分位数增加9 μg/m3，FENO预计增加24%（95% CI，15-34%）。虽然旅行前的调查结果一般是强大的，我们的旅行后的调查结果是敏感的几个有影响力的日子。细颗粒暴露导致老年人FENO水平升高，提示气道炎症增加。这些协会最好的评估期间的高个人颗粒暴露的微环境暴露测量。
Airborne particles have been linked to pulmonary oxidative stress and inflammation. Because these effects may be particularly great for traffic-related particles, we examined associations between particle exposures and exhaled nitric oxide (FENO) in a study of 44 senior citizens, which involved repeated trips aboard a diesel bus. Samples of FENO collected before and after the trips were regressed against microenvironmental and ambient particle concentrations using mixed models controlling for subject, day, trip, vitamins, collection device, mold, pollen, room air nitric oxide, apparent temperature, and time to analysis. Although ambient concentrations were collected at a fixed location, continuous group-level personal samples characterized microenvironmental exposures throughout facility and trip periods. In pre-trip samples, both microenvironmental and ambient exposures to fine particles were positively associated with FENO. For example, an interquartile increase of 4 μg/m3 in the daily microenvironmental PM2.5 concentration was associated with a 13% [95% confidence interval (CI), 2–24%) increase in FENO. After the trips, however, FENO concentrations were associated pre-dominantly with microenvironmental exposures, with significant associations for concentrations measured throughout the whole day. Associations with exposures during the trip also were strong and statistically significant with a 24% (95% CI, 15–34%) increase in FENO predicted per interquartile increase of 9 μg/m3 in PM2.5. Although pre-trip findings were generally robust, our post-trip findings were sensitive to several influential days. Fine particle exposures resulted in increased levels of FENO in elderly adults, suggestive of increased airway inflammation. These associations were best assessed by microenvironmental exposure measurements during periods of high personal particle exposures.
登录
查看更多内容
影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
DOI：
10.1007/s00420-002-0320-x
发表时间：
2002-06-01
影响因子：
3
作者：
Fischer, PH;Steerenberg, PA;van Amsterdam, JGC
通讯作者：
van Amsterdam, JGC
影响因子：
10.4
作者：
Gurgueira SA;Lawrence J;Coull B;Murthy GG;González-Flecha B
通讯作者：
González-Flecha B
影响因子：
24.3
作者：
Nicolai, T;Carr, D;von Mutius, E
通讯作者：
von Mutius, E
影响因子：
10.4
作者：
Jansen KL;Larson TV;Koenig JQ;Mar TF;Fields C;Stewart J;Lippmann M
通讯作者：
Lippmann M