Pattern of cancer/testis antigen expression in lung cancer patients.
Pattern of cancer/testis antigen expression in lung cancer patients.
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DOI：
10.3892/ijmm.2012.896
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发表时间：
2012-04
影响因子：
5.4
通讯作者：
Lee SY
中科院分区：
文献类型：
--
作者：
Kim YD;Park HR;Song MH;Shin DH;Lee CH;Lee MK;Lee SY
肿瘤/睾丸(CT)抗原是免疫治疗的良好靶点。应用RT-PCR和免疫组织化学方法分别检测了79例肺癌组织和22例肺癌组织中13种CT抗原的复合表达。在79例肺癌组织中，MAGE-3表达频率最高(42%)，其次为NY-SAR-35(33%)、NY-ESO-1(30%)、MAGE-1(27%)、CT-7(20%)、MAGE-4(19%)、LAGE-1(16%)和MAGE-10(14%)。21例组织均不表达CT抗原，58例(73%)至少表达一种，36例(46%)同时表达2种，24例(30%)同时表达3种，17例(22%)同时表达4种，14例(18%)同时表达5种，8种(10%)共表达6种，4种(6%)共表达7种，2种组织表达9种。CT抗原的表达与患者的年龄(P<；0.001)、吸烟史(P=0.009)和性别(P=0.001)显著相关，而与其他临床因素如PT状态、PN状态、肿瘤分期和组织史无关。本研究结果表明，CT抗原是肺癌患者进行多价免疫治疗的潜在候选抗原。
Cancer/testis (CT) antigens represent promising targets for immunotherapy. We investigated the composite expression of 13 CT antigens by RT-PCR in 79 lung cancer tissues and by immunohistochemistry in 22 lung cancer tissues. In the 79 lung cancer tissues, MAGE-3 (42%) was expressed most frequently and followed by NY-SAR-35 (33%), NY-ESO-1 (30%), MAGE-1 (27%), CT-7 (20%), MAGE-4 (19%), LAGE-1 (16%), and MAGE-10 (14%). Twenty-one tissues did not express any of the CT antigens tested, 58 (73%) expressed at least one, 36 (46%) co-expressed two, 24 (30%) co-expressed three, 17 (22%) co-expressed four, 14 (18%) co-expressed five, 8 (10%) co-expressed six, 4 (6%) co-expressed seven and 2 tissues expressed 9 of the 13 examined CT antigens. Expression of CT antigens was significantly associated with age (P<0.001), smoking history (P=0.009), and gender (P=0.001) of patients, whereas no correlation was found between the expression of CT antigens and other clinical factors, such as pT status, pN status, tumor stage, and histology history. The present results show that CT antigens are potential candidates in lung cancer patients for polyvalent immunotherapy.
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影响因子：
32.4
作者：
BOEL, P;WILDMANN, C;VANDERBRUGGEN, P
通讯作者：
VANDERBRUGGEN, P
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
DOI：
10.1084/jem.180.1.35
发表时间：
1994-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Coulie PG;Brichard V;Van Pel A;Wölfel T;Schneider J;Traversari C;Mattei S;De Plaen E;Lurquin C;Szikora JP;Renauld JC;Boon T
通讯作者：
Boon T
DOI：
10.1073/pnas.94.5.1914
发表时间：
1997-03-04
影响因子：
11.1
作者：
Chen, YT;Scanlan, MJ;Old, LJ
通讯作者：
Old, LJ
DOI：
10.1073/pnas.0437972100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Lee, SY;Obata, Y;Scanlan, MJ
通讯作者：
Scanlan, MJ