Beta-cell compensation and gestational diabetes.
Beta-cell compensation and gestational diabetes.
复制标题
β细胞补偿和妊娠糖尿病。
DOI：
10.1016/j.jbc.2023.105405
复制
发表时间：
2023-12
影响因子：
4.8
通讯作者：
Dong, H. Henry
中科院分区：
文献类型：
--
作者：
Usman, Taofeek O.;Chhetri, Goma;Yeh, Hsuan;Dong, H. Henry
妊娠期糖尿病（GDM）的特征是妊娠妇女的葡萄糖耐受不良，既往未诊断为糖尿病。虽然GDM的病因仍然难以捉摸，但GDM与母亲肥胖增加和孕龄提前的密切关系暗示胰岛素抵抗是GDM发病机制的一个重要因素。妊娠伴随着继发于母体体重增加的母体胰岛素抵抗的生理诱导。这种作用有助于为胎儿节省血糖。为了克服胰岛素抵抗，母体β细胞被调节以释放更多的胰岛素到血液中。这种适应性反应称为β细胞补偿，对于维持正常的母体代谢至关重要。β-细胞代偿最终导致β-细胞团的扩张和β-细胞功能的增强，导致胰岛素合成和分泌增加。因此，绝大多数母亲在怀孕期间不会患上GDM。在高危孕妇中，β细胞无法补偿母体胰岛素抵抗，导致胰岛素不足和GDM。然而，妊娠β细胞代偿在妊娠早期增强，在妊娠晚期胰岛素抵抗建立之前。β细胞如何补偿妊娠以及GDM中β细胞衰竭的原因是研究的主题。在这篇小型综述中，我们将提供临床和临床前证据，证明β细胞代偿对于克服母体胰岛素抵抗以预防GDM至关重要。我们将强调其功能对于整合妊娠激素到妊娠β细胞补偿至关重要的关键分子。我们将提供β细胞失代偿在GDM病因学中的机制见解。
Gestational diabetes mellitus (GDM) is characterized by glucose intolerance in pregnant women without a previous diagnosis of diabetes. While the etiology of GDM remains elusive, the close association of GDM with increased maternal adiposity and advanced gestational age implicates insulin resistance as a culpable factor for the pathogenesis of GDM. Pregnancy is accompanied by the physiological induction of insulin resistance in the mother secondary to maternal weight gain. This effect serves to spare blood glucose for the fetus. To overcome insulin resistance, maternal β-cells are conditioned to release more insulin into the blood. Such an adaptive response, termed β-cell compensation, is essential for maintaining normal maternal metabolism. β-cell compensation culminates in the expansion of β-cell mass and augmentation of β-cell function, accounting for increased insulin synthesis and secretion. As a result, a vast majority of mothers are protected from developing GDM during pregnancy. In at-risk pregnant women, β-cells fail to compensate for maternal insulin resistance, contributing to insulin insufficiency and GDM. However, gestational β-cell compensation ensues in early pregnancy, prior to the establishment of insulin resistance in late pregnancy. How β-cells compensate for pregnancy and what causes β-cell failure in GDM are subjects of investigation. In this mini-review, we will provide clinical and preclinical evidence that β-cell compensation is pivotal for overriding maternal insulin resistance to protect against GDM. We will highlight key molecules whose functions are critical for integrating gestational hormones to β-cell compensation for pregnancy. We will provide mechanistic insights into β-cell decompensation in the etiology of GDM.
登录
查看更多内容
影响因子：
8
作者：
Dirice, Ercument;De Jesus, Dario F.;Kulkarni, Rohit N.
通讯作者：
Kulkarni, Rohit N.
影响因子：
3.8
作者：
Bider-Canfield, Z.;Martinez, M. P.;Xiang, A. H.
通讯作者：
Xiang, A. H.
影响因子：
5.1
作者：
Crume, Tessa L.;Ogden, Lorraine;Dabelea, Dana
通讯作者：
Dabelea, Dana
影响因子：
8.2
作者：
Butler, A. E.;Cao-Minh, L.;Galasso, R.;Rizza, R. A.;Corradin, A.;Cobelli, C.;Butler, P. C.
通讯作者：
Butler, P. C.
NRF2：Beta细胞命运的主人和队长。
DOI：
10.1016/j.tem.2020.11.002
发表时间：
2021-01
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Baumel-Alterzon S;Katz LS;Brill G;Garcia-Ocaña A;Scott DK
通讯作者：
Scott DK