Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration.
Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration.
复制标题
可植入 PEKK/钽微粒复合材料，具有改善的表面性能，可调节细胞行为、促进骨形成和骨整合
DOI：
10.1016/j.bioactmat.2020.09.021
复制
发表时间：
2021-04
影响因子：
18.9
通讯作者：
Wei J
中科院分区：
文献类型：
--
作者：
Hu X;Mei S;Wang F;Qian J;Xie D;Zhao J;Yang L;Wu Z;Wei J
聚醚酮酮（PEKK）具有良好的生物相容性和机械性能，但具有生物惰性；钽（Ta）具有优异的成骨和骨整合能力，但弹性模量和密度较高，且加工难度大且成本高。本研究结合PEKK和Ta的优点，通过将PEKK与含量为20 v%（PT20）和40 v%（PT40）的Ta微粒共混制备了PEKK/Ta可植入复合材料。与PT20和PEKK相比，由于PEKK中Ta颗粒含量较高，PT40的表面亲水性、表面能、粗糙度和蛋白质吸附以及机械性能显着提高。此外，PT40表现出接近人类皮质骨的机械性能（例如抗压强度和弹性模量）。与PT20和PEKK相比，较高Ta含量的PT40显着增强MC3T3-E1细胞的体外反应（包括粘附、增殖和成骨分化）。此外，PT40 显着改善体内骨形成和骨整合。简而言之，将 Ta 微粒掺入 PEKK 中可创造出具有改善表面性能的可植入复合材料，这在刺激细胞反应/骨形成以及促进骨整合方面发挥着关键作用。 PT40可能具有作为承载熊的骨替代物的巨大潜力。通过熔融共混制备 PEKK/Ta (PT) 生物活性复合材料。随着Ta含量的增加，压缩强度、弯曲强度和弹性模量显着增加。随着Ta含量的增加，亲水性、表面能、粗糙度和蛋白质吸附显着增强。 PT40显着促进MC3T3-E1细胞的反应（粘附、增殖和成骨分化）。 PT40明显加速体内成骨和骨整合。
Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro. Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo. In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute. Bioactive composites of PEKK/Ta (PT) were fabricated by melt blending. Compressive strength, bending strength and elastic modulus significantly increased with Ta content increasing. Hydrophilicity, surface energy, roughness and protein adsorption remarkably enhanced with Ta content increasing. PT40 significantly promoted the responses (adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells. PT40 obviously accelerated osteogenesis and osseointegration in vivo.
登录
查看更多内容
影响因子：
8
作者：
Kang C;Wei L;Song B;Chen L;Liu J;Deng B;Pan X;Shao L
通讯作者：
Shao L
影响因子：
18.9
作者：
Khoury, Joseph;Selezneva, Irina;Smolkov, Alexandre
通讯作者：
Smolkov, Alexandre
影响因子：
18.9
作者：
Ouyang, Sihui;Huang, Qianli;Liang, Luxin
通讯作者：
Liang, Luxin
微弧氧化钛上锐钛矿的纳米形态、结晶度和表面电位对蛋白质吸附、细胞增殖和细胞分化的影响
DOI：
10.1016/j.msec.2019.110204
发表时间：
2020-02-01
影响因子：
7.9
作者：
Lin, Dan-Jae;Fuh, Lih-Jyh;Chen, Wen-Cheng
通讯作者：
Chen, Wen-Cheng
影响因子：
5.8
作者：
Liu, Wentao;Wang, Han;Jian, Xigao
通讯作者：
Jian, Xigao