Widespread Bordetella parapertussis Infections-Wisconsin, 2011-2012: Clinical and Epidemiologic Features and Antibiotic Use for Treatment and Prevention.
Widespread Bordetella parapertussis Infections-Wisconsin, 2011-2012: Clinical and Epidemiologic Features and Antibiotic Use for Treatment and Prevention.
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DOI：
10.1093/cid/civ514
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发表时间：
2015-11-01
期刊：
影响因子：
--
通讯作者：
Davis JP
中科院分区：
文献类型：
--
作者：
Koepke R;Bartholomew ML;Eickhoff JC;Ayele RA;Rodd D;Kuennen J;Rosekrans J;Warshauer DM;Conway JH;Davis JP
2011年10月至2012年12月，在全州范围内爆发百日咳疫情的同时，威斯康星州居民中报告了443例副百日咳杆菌感染。我们研究了百日咳患者的临床特征以及抗生素的使用对治疗和预防的影响。对2011年10月至2012年5月报告的聚合酶链式反应结果为百日咳杆菌阳性的患者进行了访谈，了解百日咳样症状的存在和持续时间以及接受阿奇霉素治疗的情况。还收集了百日咳患者家庭成员(HHMS)中急性咳嗽疾病和接受阿奇霉素预防的数据。使用多变量重复测量对数二项回归分析，我们检验了HHM接受的治疗与其他HHM中最早发病和预防接受的治疗与家庭中存在任何继发性咳嗽疾病的相关性。在218例百日咳患者中，百日咳样症状是常见的。与未接受治疗的患者相比，在咳嗽开始后0-6天开始治疗的患者的病程显著缩短(中位数分别为10天和19天，P=0.002)。在120户家庭的361名HHMS患者中，与未接受HHMS治疗的患者相比，及时预防HHMS与无继发性咳嗽相关(相对危险度：0.16；95%可信区间：0.04-0.69)。副百日咳杆菌感染会引起类似百日咳的疾病，如果不进行百日咳杆菌检测，这种疾病可能会被错误归类为百日咳。及时治疗可缩短病程，及时预防HHM可预防继发性疾病。需要进一步的研究来评估抗生素预防百日咳的有效性，并确定抗生素使用的风险和好处。
During October 2011–December 2012, concurrent with a statewide pertussis outbreak, 443 Bordetella parapertussis infections were reported among Wisconsin residents. We examined clinical features of patients with parapertussis and the effect of antibiotic use for treatment and prevention. Patients with polymerase chain reaction results positive for B. parapertussis reported during October 2011–May 2012 were interviewed regarding presence and durations of pertussis-like symptoms and receipt of azithromycin treatment. Data regarding acute cough illnesses and receipt of azithromycin prophylaxis among parapertussis patient household members (HHMs) were also collected. Using multivariate repeated measures log-binomial regression analysis, we examined associations of treatment receipt by the HHM with the earliest illness onset and prophylaxis receipt among other HHMs with the presence of any secondary cough illnesses in the household. Among 218 patients with parapertussis, pertussis-like symptoms were frequently reported. Illness durations were significantly shorter among patients with treatment initiated 0–6 days after cough onset, compared with nonrecipients (median durations: 10 vs 19 days, P = .002). Among 361 HHMs from 120 households, compared with nonrecipients, prompt prophylaxis of HHMs was associated with no secondary cough illnesses (relative risk: 0.16; 95% confidence interval, .04–.69). Bordetella parapertussis infection causes pertussis-like illness that might be misclassified as pertussis if B. parapertussis testing is not performed. Prompt treatment might shorten illness duration, and prompt HHM prophylaxis might prevent secondary illnesses. Further study is needed to evaluate antibiotic effectiveness for preventing parapertussis and to determine risks and benefits of antibiotic use.
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影响因子：
5.2
作者：
Liese, JG;Renner, C;Belohradsky, BH
通讯作者：
Belohradsky, BH
DOI：
10.1016/s1201-9712(99)90035-8
发表时间：
1999-01-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Bergfors, E;Trollfors, B;Zackrisson, G
通讯作者：
Zackrisson, G
影响因子：
3.6
作者：
HEININGER, U;STEHR, K;CHERRY, JD
通讯作者：
CHERRY, JD
影响因子：
3.6
作者：
BORTOLUSSI, R;MILLER, B;HALPERIN, S
通讯作者：
HALPERIN, S
DOI：
10.1098/rspb.2010.0010
发表时间：
2010-07-07
影响因子：
4.7
作者：
Long, Grainne H.;Karanikas, Alexia T.;Hudson, Peter J.
通讯作者：
Hudson, Peter J.