A longitudinal study of atrazine and 2,4-D exposure and oxidative stress markers among iowa corn farmers.
A longitudinal study of atrazine and 2,4-D exposure and oxidative stress markers among iowa corn farmers.
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DOI：
10.1002/em.22069
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发表时间：
2017-01
影响因子：
2.8
通讯作者：
Vermeulen RC
中科院分区：
文献类型：
--
作者：
Lerro CC;Beane Freeman LE;Portengen L;Kang D;Lee K;Blair A;Lynch CF;Bakke B;De Roos AJ;Vermeulen RC
活性氧，可能通过环境暴露形成，可以压倒生物体的抗氧化能力，导致氧化应激。长期氧化应激与慢性疾病有关。农药暴露已被证明会引起体内氧化应激。我们对爱荷华州的玉米种植者和非农业对照进行了纵向研究，以检验暴露于广泛使用的除草剂阿特拉津和2,4-二氯苯氧乙酸（2,4- d）对氧化应激标志物的影响。在5个农业时期（种植前、种植、生长、收获、淡季）收集了225份尿样，其中30名农民职业使用农药，10名对照不使用农药；所有人都是年龄在40-60岁之间的不吸烟男性。测定尿中阿特拉津汞（阿特拉津代谢物）、2,4- d和氧化应激标志物（丙二醛[MDA]、8-羟基-2 ' -脱氧鸟苷[8-OHdG]和8-异前列腺素- f2 α [8-isoPGF]）。我们使用多元线性混合效应模型计算了每种农药-氧化应激标志物组合的β估计值和95%置信区间（95% ci）。与对照组相比，农民尿液中的阿特拉津和2,4- d含量较高。在回归模型中，经过自然对数变换，2,4- d与8-OHdG （β=0.066, 95%CI= 0.008-0.124）和8-isoPGF （β=0.088, 95%CI= 0.004-0.172）水平升高相关。2,4- d可能与氧化应激有关，因为随着2,4- d暴露，8-OHdG （DNA氧化损伤的标志）和8-isoPGF（脂蛋白过氧化的产物）的适度增加。未来的研究应探讨2,4- d诱导的氧化应激在人类疾病发病机制中的作用。
Reactive oxygen species, potentially formed through environmental exposures, can overwhelm an organism’s antioxidant capabilities resulting in oxidative stress. Long-term oxidative stress is linked with chronic diseases. Pesticide exposures have been shown to cause oxidative stress in vivo. We utilized a longitudinal study of corn farmers and non-farming controls in Iowa to examine the impact of exposure to the widely used herbicides atrazine and 2,4-dichlorophenoxyacetic acid (2,4-D) on markers of oxidative stress. 225 urine samples were collected during five agricultural time periods (pre-planting, planting, growing, harvest, off-season) for 30 farmers who applied pesticides occupationally and 10 controls who did not; all were non-smoking men ages 40–60. Atrazine mercapturate (atrazine metabolite), 2,4-D, and oxidative stress markers (malondialdehyde [MDA], 8-hydroxy-2′-deoxyguanosine [8-OHdG], and 8-isoprostaglandin-F2α [8-isoPGF]) were measured in urine. We calculated β estimates and 95% confidence intervals (95%CI) for each pesticide-oxidative stress marker combination using multivariate linear mixed-effect models for repeated measures. Farmers had higher urinary atrazine mercapturate and 2,4-D levels compared to controls. In regression models, after natural log transformation, 2,4-D was associated with elevated levels of 8-OHdG (β=0.066, 95%CI=0.008–0.124) and 8-isoPGF (β=0.088, 95%CI=0.004–0.172). 2,4-D may be associated with oxidative stress because of modest increases in 8-OHdG, a marker of oxidative DNA damage, and 8-isoPGF, a product of lipoprotein peroxidation, with recent 2,4-D exposure. Future studies should investigate the role of 2,4-D-induced oxidative stress in the pathogenesis of human diseases.
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影响因子：
4.5
作者：
通讯作者：
--
影响因子：
3.5
作者：
Banerjee, BD;Seth, V;Chakraborty, AK
通讯作者：
Chakraborty, AK
小鼠接触莠去津及其代谢物二氨基氯三嗪会引起氧化应激和内分泌干扰
影响因子：
4.3
作者：
Jin, Yuanxiang;Wang, Linggang;Fu, Zhengwei
通讯作者：
Fu, Zhengwei
影响因子：
5
作者：
Block, G;Dietrich, M;Packer, L
通讯作者：
Packer, L
影响因子：
5
作者：
Berg, KJ;Kristoffersen, DT;Stenstrom, J
通讯作者：
Stenstrom, J