Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan.
Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan.
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DOI：
10.1016/j.vetimm.2011.12.023
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发表时间：
2012-01-15
影响因子：
1.8
通讯作者：
Sakaguchi M
中科院分区：
文献类型：
--
作者：
Miyaji K;Suzuki A;Shimakura H;Takase Y;Kiuchi A;Fujimura M;Kurita G;Tsujimoto H;Sakaguchi M
犬非狂犬病联合疫苗广泛用于保护动物免受传染源的侵害，在公共卫生中也发挥着重要作用。我们在2006年4月1日至2007年5月31日期间向动物医院分发了VAAE调查问卷，在日本进行了一项大规模调查，以调查包括过敏反应在内的疫苗相关不良事件（VAAE）。在573家动物医院的57,300只接种疫苗的狗中获得了有效答复；我们获得了各兽医医院最后 100 只接种疫苗的狗的 VAAE 信息。我们发现，在 57,300 只狗中，有 359 只表现出了 VAAE。在 359 只狗中，死亡 1 只，过敏反应 41 只，皮肤病症状 244 只，胃肠道症状 160 只，其他症状 106 只。VAAE 的发病大多在疫苗接种后 12 小时内观察到（n = 299，83.3%）。在这项研究中，过敏反应事件发生在接种疫苗后 60 分钟内，其中大约一半的事件发生在 5 分钟内（n = 19，46.3%）。此外，在报告过敏反应的情况下，通过重新调查获得了支持诊断的额外信息。我们对患有过敏反应的狗进行了重新调查，其中 31 只狗出现了反应；其中 27 例出现虚脱（87.1%），24 例出现紫绀（77.4%），22 例（71.0%）同时出现两种体征。日本的动物 VAAE、过敏反应和死亡率高于其他国家。有必要进行进一步的调查，包括调查研究，以阐明死亡和疫苗接种之间的相互作用以及 VAAE 的危险因素，从而开发更安全的疫苗。此外，可能还需要不断更新 VAAE 的数据。
Canine non-rabies combined vaccines are widely used to protect animals from infectious agents, and also play an important role in public health. We performed a large-scale survey to investigate vaccine-associated adverse events (VAAEs), including anaphylaxis, in Japan by distributing questionnaires on VAAEs to veterinary hospitals from April 1, 2006 through May 31, 2007. Valid responses were obtained for 57,300 vaccinated dogs at 573 animal hospitals; we obtained VAAEs information for last 100 vaccinated dogs in each veterinary hospital. We found that of the 57,300, 359 dogs showed VAAEs. Of the 359 dogs, death was observed in 1, anaphylaxis in 41, dermatological signs in 244, gastrointestinal signs in 160, and other signs in 106. Onset of VAAEs was mostly observed within 12 h after vaccination (n = 299, 83.3%). In this study, anaphylaxis events occurred within 60 min after vaccination, and about half of these events occurred within 5 min (n = 19, 46.3%). Furthermore, where anaphylaxis was reported, additional information to support the diagnosis was obtained by reinvestigation. Our resurvey of dogs with anaphylaxis yielded responses on 31 dogs; 27 of these demonstrated collapse (87.1%), 24 demonstrated cyanosis (77.4%), and both signs occurred in 22 (71.0%). Higher rates of animal VAAEs, anaphylaxis, and death were found in Japan than in other countries. Further investigations, including survey studies, will be necessary to elucidate the interaction between death and vaccination and the risk factors for VAAEs, and thus develop safer vaccines. Moreover, it may also be necessary to continually update the data of VAAEs.
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影响因子：
2.2
作者：
Ohmori, K;Sakaguchi, M;Tsujimoto, H
通讯作者：
Tsujimoto, H
影响因子：
5.5
作者：
Sakaguchi, M;Nakayama, T;Inouye, S
通讯作者：
Inouye, S
DOI：
10.1007/s11882-001-0091-6
发表时间：
2001-01-01
期刊：
Current allergy reports
影响因子：
--
作者：
Georgitis, J W;Fasano, M B
通讯作者：
Fasano, M B
影响因子：
1.8
作者：
Ohmori, K;Masuda, K;Sakaguchi, M
通讯作者：
Sakaguchi, M
影响因子：
1.8
作者：
Ohmori K;Masuda K;DeBoer DJ;Sakaguchi M;Tsujimoto H
通讯作者：
Tsujimoto H