The association between endometriosis and chronic endometritis.

The association between endometriosis and chronic endometritis.
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DOI:
10.1371/journal.pone.0088354
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发表时间:
2014
期刊:
影响因子:
3.7
通讯作者:
Murakami T
Murakami T
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Takebayashi A;Kimura F;Kishi Y;Ishida M;Takahashi A;Yamanaka A;Takahashi K;Suginami H;Murakami T

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评估子宫内膜异位症与慢性子宫内膜炎之间的关联。子宫内膜标本取自71例接受子宫切除术的患者,其中34例有子宫内膜异位症(子宫内膜异位症组),37例无子宫内膜异位症(非子宫内膜异位症组),并对标本进行浆细胞标志物CD138免疫染色。比较子宫内膜异位症组与非子宫内膜异位症组慢性子宫内膜炎的发生率。此外,71例患者还被分为两组,28例患有慢性子宫内膜炎(慢性子宫内膜炎组),43例无慢性子宫内膜炎(非慢性子宫内膜炎组)。对年龄、体重指数(BMI)、妊娠和产次以及病理诊断为平滑肌瘤、子宫腺肌病和子宫内膜异位症等变量进行Logistic回归分析,以检验各变量对慢性子宫内膜炎的独立影响。患有宫颈浸润癌、子宫内膜癌和子宫内膜息肉的患者或术前接受促性腺激素释放激素激动剂、孕激素或口服避孕药治疗的患者被排除。子宫内膜异位症组中 52.94% 患有慢性子宫内膜炎,非子宫内膜异位症组中 27.02% 患有慢性子宫内膜炎 (p<0.05)。 Logistic回归分析显示子宫内膜异位症与慢性子宫内膜炎相关。这一结果表明子宫内膜异位症和慢性子宫内膜炎之间存在密切关联。
To evaluate the association between endometriosis and chronic endometritis. Endometrial specimens were obtained from 71 patients, 34 with endometriosis (endometriosis group) and 37 without endometriosis (non-endometriosis group), who underwent hysterectomy, and the specimens were immunostained for the plasmacyte marker CD138. The rate of chronic endometritis was compared between the endometriosis group and the non-endometriosis group. Furthermore, the 71 patients were also divided into two groups, 28 with chronic endometritis (chronic endometritis group) and 43 without chronic endometritis (non-chronic endometritis group). Logistic regression analysis was performed with variables including age, body mass index (BMI), gravidity and parity, and diagnoses of leiomyoma, adenomyosis, and endometriosis on pathology to examine the independent effect of each variable on chronic endometritis. Patients suffering from cervical invasive carcinoma, endometrial carcinoma, and endometrial polyps or treated with gonadotropin-releasing hormone agonists, progestins, or oral contraceptives before surgery were excluded. Chronic endometritis was identified in 52.94% of the endometriosis group and 27.02% of the non-endometriosis group (p<0.05). Logistic regression analysis revealed that endometriosis was associated with chronic endometritis. This result suggests a strong association between endometriosis and chronic endometritis.
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