Microneedle arrays for the treatment of chronic wounds.
Microneedle arrays for the treatment of chronic wounds.
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DOI：
10.1080/17425247.2020.1819787
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发表时间：
2020-12
影响因子：
6.6
通讯作者：
Tamayol A
中科院分区：
文献类型：
--
作者：
Barnum L;Samandari M;Schmidt TA;Tamayol A
慢性伤口常见于糖尿病和卧床病人。这种不能及时愈合的皮肤损伤会导致危及生命的疾病。为了解决慢性伤口的负担，许多研究已经探索了各种治疗方法对伤口愈合的疗效。治疗药物可以局部递送到皮肤伤口，以减少与全身药物递送相关的并发症，因为受损的皮肤屏障预计不会对药物分布产生负面影响。然而，研究人员最近证明，慢性伤口的复杂环境可能会降低局部应用治疗的可用性。微针阵列（MNAs）可以用来提高输送效率，从而改善愈合。在这篇综述中，我们简要介绍了慢性伤口的病理生理和目前的治疗策略。我们进一步介绍了制备MNAs的常用方法和材料。随后，研究证明了MNAs在伤口护理中的益处。微针在治疗复杂的慢性伤口病理生理方面具有很大的潜力。需要解决的挑战包括开发强大的慢性伤口模型和将复杂功能与简单使用相结合的MNAs。
Chronic wounds are seen frequently in diabetic and bedbound patients. Such skin injuries, which do not heal in a timely fashion, can lead to life-threatening conditions. In an effort to resolve the burdens of chronic wounds, numerous investigations have explored the efficacy of various therapeutics on wound healing. Therapeutics can be topically delivered to cutaneous wounds to reduce the complications associated with systemic drug delivery because the compromised skin barrier is not expected to negatively affect drug distribution. However, researchers have recently demonstrated that the complex environment of chronic wounds could lower the localized availability of the applied therapeutics. Microneedle arrays (MNAs) can be exploited to enhance delivery efficiency and consequently improved healing. In this review, we briefly describe the pathophysiology of chronic wounds and current treatment strategies. We further introduce methods and materials commonly used for the fabrication of MNAs. Subsequently, the studies demonstrating the benefits of MNAs in wound care are highlighted. Microneedles have great potential to treat the complicated pathophysiology of chronic wounds. Challenges that will need to be addressed include development of a robust chronic wound model and MNAs that combine complex functionality with simplicity of use.
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DOI：
10.2147/ccid.s50046
发表时间：
2014
期刊：
Clinical, cosmetic and investigational dermatology
影响因子：
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作者：
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影响因子：
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发表时间：
2018-07-31
期刊：
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通讯作者：
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DOI：
10.1098/rstb.2004.1475
发表时间：
2004-05-29
影响因子：
6.3
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