Structural and functional rich club organization of the brain in children and adults.
Structural and functional rich club organization of the brain in children and adults.
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DOI：
10.1371/journal.pone.0088297
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fair DA
中科院分区：
文献类型：
--
作者：
Grayson DS;Ray S;Carpenter S;Iyer S;Dias TG;Stevens C;Nigg JT;Fair DA
最近使用核磁共振成像（MRI）的研究表明，大脑的白质就像一个富人俱乐部一样组织起来，大脑中联系最紧密的区域彼此之间也高度相连。在这里，我们在人脑中使用功能性和弥散加权MRI来研究富俱乐部现象是否存在功能连接，以及这种组织与结构现象之间的关系。我们还研究了富裕俱乐部区域是否有助于不同大脑系统之间的信息整合，并对富裕俱乐部现象的发展轨迹进行了简要调查。与先前的研究一致，成人和儿童都表现出强大的结构丰富的俱乐部组织，包括上内侧额叶/dACC，内侧顶叶/PCC，岛叶和下颞叶皮层。我们还表明，这些区域在大脑的主要网络中高度整合。功能性大脑网络在相似的空间布局中具有丰富的俱乐部现象，但系统之间存在高度隔离。虽然成人和儿童在结构上没有显著差异，但成人的俱乐部组织功能显著增强。这种差异似乎是由顶叶上皮层、脑岛皮层和边缘上皮层之间的一组特定连接所驱动的。总之，这项工作强调了在成人和儿童人群中存在一个结构和功能丰富的俱乐部，在发展过程中存在一些功能变化。它还提供了一个潜在的目标，以检查非典型的网络组织在常见的发育性大脑疾病，如多动症和自闭症。
Recent studies using Magnetic Resonance Imaging (MRI) have proposed that the brain’s white matter is organized as a rich club, whereby the most highly connected regions of the brain are also highly connected to each other. Here we use both functional and diffusion-weighted MRI in the human brain to investigate whether the rich club phenomena is present with functional connectivity, and how this organization relates to the structural phenomena. We also examine whether rich club regions serve to integrate information between distinct brain systems, and conclude with a brief investigation of the developmental trajectory of rich-club phenomena. In agreement with prior work, both adults and children showed robust structural rich club organization, comprising regions of the superior medial frontal/dACC, medial parietal/PCC, insula, and inferior temporal cortex. We also show that these regions were highly integrated across the brain’s major networks. Functional brain networks were found to have rich club phenomena in a similar spatial layout, but a high level of segregation between systems. While no significant differences between adults and children were found structurally, adults showed significantly greater functional rich club organization. This difference appeared to be driven by a specific set of connections between superior parietal, insula, and supramarginal cortex. In sum, this work highlights the existence of both a structural and functional rich club in adult and child populations with some functional changes over development. It also offers a potential target in examining atypical network organization in common developmental brain disorders, such as ADHD and Autism.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
3
作者：
Hagmann P;Grant PE;Fair DA
通讯作者：
Fair DA
DOI：
10.1073/pnas.0811168106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Honey, C. J.;Sporns, O.;Hagmann, P.
通讯作者：
Hagmann, P.