Antibacterial, antifungal, and antiviral effects of three essential oil blends.
Antibacterial, antifungal, and antiviral effects of three essential oil blends.
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DOI：
10.1002/mbo3.459
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发表时间：
2017-08
期刊：
影响因子：
3.4
通讯作者：
Roques C
中科院分区：
文献类型：
--
作者：
Brochot A;Guilbot A;Haddioui L;Roques C
需要对常见病原体有效的新试剂，特别是对那些对常规抗微生物剂具有抗性的病原体。精油（EO）因其抗菌活性而闻名。使用肉汤微量稀释法，我们表明（1）肉桂、胡萝卜、蓝桉和迷迭香EO的两种独特混合物（AB 1和AB 2;来自两个不同供应商的肉桂EO）对14种测试的革兰氏阳性和阴性细菌菌株具有活性，包括一些抗生素耐药菌株。最小抑菌浓度（MIC）范围为0.01%至3%v/v，最小杀菌浓度为<0.01%至6.00%v/v;（2）锡兰肉桂、胡萝卜、丁香、牛至的混合物对供试的6株念珠菌具有抑菌作用，MIC范围为0.01%至0.05%v/v，最小杀真菌浓度为0.02%至0.05%v/v。共混物AB 1也有效对抗H1N1和HSV 1病毒。由于这种双重活性，特别是抗H1N1和抗金黄色葡萄球菌和肺炎链球菌的双重活性，AB 1可能对治疗流感和流感后细菌性肺炎感染感兴趣。这些共混物在临床实践中可能非常有用，以对抗常见感染，包括由抗微生物药物耐药的微生物引起的感染。
New agents that are effective against common pathogens are needed particularly for those resistant to conventional antimicrobial agents. Essential oils (EOs) are known for their antimicrobial activity. Using the broth microdilution method, we showed that (1) two unique blends of Cinnamomum zeylanicum, Daucus carota, Eucalyptus globulus and Rosmarinus officinalis EOs (AB1 and AB2; cinnamon EOs from two different suppliers) were active against the fourteen Gram‐positive and ‐negative bacteria strains tested, including some antibiotic‐resistant strains. Minimal inhibitory concentrations (MICs) ranged from 0.01% to 3% v/v with minimal bactericidal concentrations from <0.01% to 6.00% v/v; (2) a blend of Cinnamomum zeylanicum, Daucus carota, Syzygium aromaticum, Origanum vulgare EOs was antifungal to the six Candida strains tested, with MICs ranging from 0.01% to 0.05% v/v with minimal fungicidal concentrations from 0.02% to 0.05% v/v. Blend AB1 was also effective against H1N1 and HSV1 viruses. With this dual activity, against H1N1 and against S. aureus and S. pneumoniae notably, AB1 may be interesting to treat influenza and postinfluenza bacterial pneumonia infections. These blends could be very useful in clinical practice to combat common infections including those caused by microorganisms resistant to antimicrobial drugs.
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