Domain-specific expression of meristematic genes is defined by the LITTLE ZIPPER protein DTM in tomato

Domain-specific expression of meristematic genes is defined by the LITTLE ZIPPER protein DTM in tomato
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番茄中 LITTLE ZIPPER 蛋白 DTM 定义了分生组织基因的域特异性表达

DOI:
10.1038/s42003-019-0368-8
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发表时间:
2019-04
影响因子:
5.9
通讯作者:
Xiao Han
Xiao Han
中科院分区:
生物学2区
文献类型:
--
作者:
Xu Qian;Li Rong;Weng Lin;Sun Yuan;Li Meng;Xiao Han

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茎分生组织是植物地上部分新器官产生的关键,它含有少量的干细胞。这些干细胞的增殖和分化受涉及两个关键分生组织基因的遗传途径调节:CLAVATA 3(CLV 3)和WUSCHEL(WUS)。然而,CLV 3和WUS在茎分生组织中的表达结构域在胚发生后的发育过程中是如何被指定和维持的还不清楚。在这里,我们表明,一个番茄突变体与扁化茎,花和果实,由于受损的干细胞活性,是有缺陷的小拉链基因表示为缺陷番茄分生组织(DTM)。DTM与III类同源结构域-亮氨酸拉链(HD-ZIP III)转录因子形成负反馈环,将CLV 3和WUS表达限制在茎分生组织的特定结构域。我们的发现揭示了植物干细胞稳态调节的新的复杂性。
Shoot meristems, which harbor a small population of stem cells, are responsible for generating new above-ground organs in plants. The proliferation and differentiation of these stem cells is regulated by a genetic pathway involving two key meristematic genes:CLAVATA3(CLV3) andWUSCHEL(WUS). However, it is not well understood howCLV3andWUSexpression domains in the shoot meristems are specified and maintained during post-embryogenic development. Here, we show that a tomato mutant with fasciated stems, flowers and fruits, due to impaired stem cell activity, is defective in a LITTLE ZIPPER gene denoted asDEFECTIVE TOMATO MERISTEM(DTM). DTM forms a negative feedback loop with class III homeodomain-leucine zipper (HD-ZIP III) transcription factors to confineCLV3andWUSexpression to specific domains of the shoot meristems. Our findings reveal a new layer of complexity in the regulation of plant stem cell homeostasis.
DOI: 10.1371/journal.pgen.1006168
发表时间: 2016-07
期刊: PLoS genetics
影响因子: 4.5
作者:
Shi B;Zhang C;Tian C;Wang J;Wang Q;Xu T;Xu Y;Ohno C;Sablowski R;Heisler MG;Theres K;Wang Y;Jiao Y
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发表时间: 1999-03-19
期刊: SCIENCE
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作者:
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期刊: Development
影响因子: 4.6
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DOI: 10.1104/pp.114.255174
发表时间: 2015-01
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影响因子: 7.4
作者:
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