Foveal cone photoreceptor involvement in primary open-angle glaucoma.
Foveal cone photoreceptor involvement in primary open-angle glaucoma.
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DOI：
10.1007/s00417-010-1331-z
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
van Norren D
中科院分区：
文献类型：
--
作者：
Kanis MJ;Lemij HG;Berendschot TT;van de Kraats J;van Norren D
目的：检测原发性开角型青光眼（POAG）患者中央凹视锥细胞是否受损。19只POAG患眼有中央性青光眼视野缺损，34只年龄匹配的对照眼被纳入研究。眼底反射仪，连同模型拟合程序，提供了一组参数的信息：透镜光密度，黄斑色素光密度，黑色素，血液，定向锥反射率（Rd），测量中心凹锥光感受器的完整性，和RILM，反射率在内界膜。进行光学相干断层扫描（OCT）以评估黄斑厚度。使用Kolmogorov-Smirnov Z检验比较两组之间的参数。对照组受试者的中位年龄（范围）为55.1（24.7-73.3）岁，POAG患者为60.1（20.7-77.0）岁（P = 0.24）。在所有8个模型参数中，只有Rd和RILM在POAG中显著降低。对照组的中位Rd（范围）为2.21（0.64-4.93）%，POAG患者为1.19（0.08-3.60）%（P = 0.003）。对照组RILM中位数为0.15（0.00-1.08）%，POAG组为0.08（0.01-0.29）%（P < 0.001）。POAG患者视野检查的Rd与中央视网膜敏感度无线性关系。在OCT上，以中央凹为中心的1-3 mm内环和3-6 mm外环的视网膜厚度在POAG患者中显著低于对照受试者。POAG合并晚期中央视野缺损时，中心凹锥体外节的完整性和中央ILM的反射率受损。
To test whether foveal cone photoreceptors are impaired in primary open-angle glaucoma (POAG). Nineteen POAG eyes with central glaucomatous visual field defects, and 34 age-matched control eyes were included. Fundus reflectometry, together with a model fit procedure, provided information on a set of parameters: lens optical density, macular pigment optical density, melanin, blood, the directional cone reflectance (Rd), a measure for foveal cone photoreceptor integrity, and RILM, the reflectance at the inner limiting membrane. Optical coherence tomography (OCT) was performed to assess macular thickness. A Kolmogorov–Smirnov Z-test was used to compare parameters between the two groups. Median age (range) was 55.1 (24.7–73.3) years in the control subjects, and 60.1 (20.7–77.0) years in the POAG patients (P = 0.24). Of all eight model parameters, only Rd and RILM were significantly lower in POAG. Median Rd (range) was 2.21 (0.64–4.93) % in the control subjects and 1.19 (0.08–3.60) % in the POAG patients (P = 0.003). Median RILM (range) was 0.15 (0.00–1.08) % in the control subjects, and 0.08 (0.01–0.29) % in the POAG patients (P < 0.001). Rd showed no linear relationship with central retinal sensitivity on Visual Field test in POAG patients. Retinal thickness of the inner 1–3 mm ring and the outer 3–6 mm ring on OCT, centered on the fovea, was significantly lower in POAG patients than in control subjects. The integrity of the foveal cone outer segments, and the reflectance of the central ILM were impaired in POAG with advanced central visual field defects.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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