Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?
Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?
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DOI：
10.1016/j.it.2013.02.007
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发表时间：
2013-08
影响因子：
16.8
通讯作者：
Adema GJ
中科院分区：
文献类型：
--
作者：
Nierkens S;Tel J;Janssen E;Adema GJ
抗原交叉呈递描述了树突状细胞（DC）获得外源性抗原以呈递在MHC I类分子上的过程。交叉呈递的能力被认为是特化DC亚群的特征。然而，新出现的数据表明，每个DC亚群的交叉呈递能力由几个因素调节并依赖于几个因素，如DC位置和激活状态，以及抗原和炎症信号的类型。因此，我们认为，交叉呈递的能力不是一个或几个不同的DC亚型的独有特征，而是小鼠和人类DC家族的共同特征。了解DC亚群激活和抗原呈递途径可能会产生改进的工具和靶点，以利用DC在免疫治疗中独特的交叉呈递能力。
Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each DC subset is tuned by and dependent on several factors, such as DC location and activation status, and the type of antigen and inflammatory signals. Thus, we argue that capacity of cross-presentation is not an exclusive trait of one or several distinct DC subtypes, but rather a common feature of the DC family in both mice and humans. Understanding DC subset activation and antigen-presentation pathways might yield improved tools and targets to exploit the unique cross-presenting capacity of DCs in immunotherapy.
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DOI：
10.1038/jid.2009.343
发表时间：
2010-03
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.5
作者：
Bedoui, Sammy;Whitney, Paul G.;Heath, William R.
通讯作者：
Heath, William R.
影响因子：
6.4
作者：
Askew, David;Harding, Clifford V.
通讯作者：
Harding, Clifford V.
影响因子：
5.4
作者：
Backer, Ronald;van Leeuwen, Fred;den Haan, Joke M. M.
通讯作者：
den Haan, Joke M. M.
CD8α(+)树突状细胞负责诱导外周组织相关抗原的自身耐受。
影响因子：
15.3
作者：
Belz, Gabrielle T;Behrens, Georg M N;Smith, Chris M;Miller, Jacques F A P;Jones, Claerwen;Lejon, Kristina;Fathman, C Garrison;Mueller, Scott N;Shortman, Ken;Carbone, Francis R;Heath, William R
通讯作者：
Heath, William R