Regulation of lymph node vascular growth by dendritic cells.
Regulation of lymph node vascular growth by dendritic cells.
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DOI：
10.1084/jem.20052272
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发表时间：
2006-08-07
期刊：
影响因子：
--
通讯作者：
Lu TT
中科院分区：
文献类型：
--
作者：
Webster B;Ekland EH;Agle LM;Chyou S;Ruggieri R;Lu TT
淋巴结在免疫反应开始时快速而稳健地生长，并且这种生长伴随着血管的生长。虽然血管对于提供营养和控制细胞运输是至关重要的，但淋巴结血管生长的调节还不清楚。我们发现，淋巴结内皮细胞开始增殖2天内免疫，并进行相应的细胞数量的扩增。内皮细胞增殖依赖于CD11c+树突状细胞（DC），皮下注射DC足以触发内皮细胞增殖和生长。淋巴结内皮细胞增殖依赖于血管内皮生长因子（VEGF），DC与淋巴结VEGF水平升高相关。DC诱导的内皮细胞增殖和VEGF水平增加是由DC诱导的造血细胞募集介导的。引流淋巴结中的血管生长包括高内皮微静脉内皮细胞的生长，并且在功能上与增加的细胞进入淋巴结相关。总的来说，我们的研究结果表明，引流淋巴结中的内皮细胞扩增是由DC诱导的，作为优化随后免疫应答微环境的程序的一部分。
Lymph nodes grow rapidly and robustly at the initiation of an immune response, and this growth is accompanied by growth of the blood vessels. Although the vessels are critical for supplying nutrients and for controlling cell trafficking, the regulation of lymph node vascular growth is not well understood. We show that lymph node endothelial cells begin to proliferate within 2 d of immunization and undergo a corresponding expansion in cell numbers. Endothelial cell proliferation is dependent on CD11c+ dendritic cells (DCs), and the subcutaneous injection of DCs is sufficient to trigger endothelial cell proliferation and growth. Lymph node endothelial cell proliferation is dependent on vascular endothelial growth factor (VEGF), and DCs are associated with increased lymph node VEGF levels. DC-induced endothelial cell proliferation and increased VEGF levels are mediated by DC-induced recruitment of blood-borne cells. Vascular growth in the draining lymph node includes the growth of high endothelial venule endothelial cells and is functionally associated with increased cell entry into the lymph node. Collectively, our results suggest a scenario whereby endothelial cell expansion in the draining lymph node is induced by DCs as part of a program that optimizes the microenvironment for the ensuing immune response.
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通过预防新血管形成，体内肿瘤休眠。
影响因子：
15.3
作者：
Gimbrone, M A Jr;Leapman, S B;Cotran, R S;Folkman, J
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Folkman, J