Structural Modulation of Gut Microbiota during Alleviation of Suckling Piglets Diarrhoea with Herbal Formula.
Structural Modulation of Gut Microbiota during Alleviation of Suckling Piglets Diarrhoea with Herbal Formula.
复制标题
用草药配方缓解乳猪腹泻期间肠道微生物群的结构调节
DOI：
10.1155/2017/8358151
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Guo S
中科院分区：
文献类型：
--
作者：
Liu C;Zhang C;Lv W;Chao L;Li Z;Shi D;Guo S
为探讨中药复方参苓白术汤对哺乳仔猪肠道菌群组成的调节作用及对腹泻的缓解作用，选取24头新生仔猪（大白色×长×杜），随机分为4组（对照组、试验Ⅰ、Ⅱ、Ⅲ组）。通过16 S rRNA基因454-焦磷酸测序评估粪便微生物组组成。结果表明，实验组I和II表现出与对照组显著不同的肠道微生物群。其中乳杆菌属和双歧杆菌属在实验组Ⅱ较对照组显著升高（P < 0.05）。实验Ⅱ组大肠杆菌、粪杆菌数量较对照组明显增加（P < 0.05）。结果表明，SLB处理可以调节哺乳仔猪肠道菌群组成，特别是富集有益菌的数量。观察到的肠道菌群变化可为进一步研究受试中药复方的药理机制提供基础。
To determine whether the traditional Chinese herbal formula of Shen Ling Baizhu (SLB) could modulate the composition of the gut microbiota and alleviate diarrhoea in suckling piglets, twenty-four newly born piglets (Large White × Landrace × Duroc) were selected and allocated to 4 groups (control group and experimental groups I, II, and III) randomly. Faecal microbiome composition was assessed by 16S rRNA gene 454-pyrosequencing. The result indicated that experimental groups I and II exhibited significantly different gut microbiota from the control group. Most notably, the genera Lactobacillus and Bifidobacterium were significantly elevated in experimental group II compared with the control group (P < 0.05). Collinsella and Faecalibacterium were also enhanced in experimental group II compared with the control group (P < 0.05). The results showed that SLB treatment could modulate the gut microbiota composition of suckling piglets, enriching the amount of beneficial bacteria in particular. The observed changes in the gut microbiota could provide the basis for further research on the pharmacological mechanism of the tested Chinese herbal formula.
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影响因子：
10.7
作者：
Price MN;Dehal PS;Arkin AP
通讯作者：
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影响因子：
4.4
作者：
Schloss, Patrick D.;Westcott, Sarah L.;Weber, Carolyn F.
通讯作者：
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影响因子：
4.9
作者：
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影响因子：
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作者：
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通讯作者：
Huttenhower, Curtis
DOI：
10.1073/pnas.0804812105
发表时间：
2008-10-28
影响因子：
11.1
作者：
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通讯作者：
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