Synthesis, characterization, and X-ray attenuation properties of ultrasmall BiOI nanoparticles: toward renal clearable particulate CT contrast agents.
Synthesis, characterization, and X-ray attenuation properties of ultrasmall BiOI nanoparticles: toward renal clearable particulate CT contrast agents.
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超小 BiOI 纳米颗粒的合成、表征和 X 射线衰减特性：面向肾脏可清除颗粒 CT 造影剂。
DOI：
10.1021/ic5011709
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发表时间：
2014-10-06
影响因子：
4.6
通讯作者：
Huang SD
中科院分区：
文献类型：
--
作者：
Kandanapitiye MS;Gao M;Molter J;Flask CA;Huang SD
本文开发并报道了一种独特的减速水解工艺，用于制备具有窄尺寸分布（即2.8±0.5 nm）的pvp包被BiOI的超小纳米颗粒（NPs）。该化合物的晶体结构是用块状材料的x射线粉末衍射测定的。研究了pvp包被的超小BiOI NPs作为CT造影剂的稳定性、细胞毒性和潜在用途。由于铋和碘的联合x射线衰减效应，这种NPs的CT值是文献中报道的无机纳米颗粒基CT造影剂中最好的。在I -离子和聚合物包覆剂的存在下，在酸性条件下控制水解生成BiO+离子，形成尺寸分布窄（~ 2.8±0.5 nm）的超小纳米颗粒。这种纳米颗粒具有非常高的x射线衰减能力，可以很容易地通过内吞作用被HeLa细胞内化，这表明它们具有作为细胞x射线CT造影剂的潜力。
A unique decelerated hydrolytic procedure is developed and reported here for the preparation of ultrasmall nanoparticles (NPs) of PVP-coated BiOI with a narrow size distribution, i.e., 2.8 ± 0.5 nm. The crystal structure of this compound is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, and potential use of the PVP-coated ultrasmall BiOI NPs as a CT contrast agent are investigated. Because of the combined X-ray attenuation effect of bismuth and iodine, such NPs exhibit a CT value that is among the best of those of the inorganic nanoparticle-based CT contrast agents reported in the literature. The controlled hydrolysis reaction for producing BiO+ ions under acidic conditions in the presence of I− ions and a polymer coating agent leads to the formation of ultrasmall nanoparticles with a narrow size distribution (∼2.8 ± 0.5 nm). Such nanoparticles possess very high X-ray attenuation power and can be readily internalized by HeLa cells via endocytosis, suggesting their potential as a cellular X-ray CT contrast agent.
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17.1
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