Learning-dependent neuronal activity across the larval zebrafish brain.

Learning-dependent neuronal activity across the larval zebrafish brain.
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DOI:
10.1016/j.conb.2020.07.006
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发表时间:
2021-04
影响因子:
5.7
通讯作者:
Lovett-Barron M
Lovett-Barron M
中科院分区:
医学2区
文献类型:
--
作者:
Lovett-Barron M

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学习改变了跨多个大脑区域的神经元的活动,但这种分布式组织的意义仍然鲜为人知,部分原因是在常用的哺乳动物模型系统中观察全脑活动模式很困难。这篇综述讨论了利用斑马鱼幼体的小的和可光学访问的神经系统来研究编码经验的全脑网络的前景。我讨论了在斑马鱼幼体中研究学习和记忆的机会和挑战,从最近经验依赖型行为的全脑成像研究中吸取的教训,以及使用斑马鱼神经技术来理解分布式记忆网络的生理原理和行为意义的潜力。
Learning changes the activity of neurons across multiple brain regions, but the significance of this distributed organization remains poorly understood, owing in part to the difficulty of observing brain-wide activity patterns in commonly used mammalian model systems. This review discusses the promise of using the small and optically accessible nervous system of larval zebrafish to study the brain-wide networks that encode experience. I discuss the opportunities and challenges of studying learning and memory in the larval zebrafish, the lessons learned from recent studies of brain-wide imaging during experience-dependent behavior, and the potential for using zebrafish neurotechnology to understand the physiological principles and behavioral significance of distributed memory networks.
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