Alteration of fimbriation and cell hydrophobicity by sublethal concentrations of tetracycline.
Alteration of fimbriation and cell hydrophobicity by sublethal concentrations of tetracycline.
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亚致死浓度的四环素改变纤维和细胞疏水性。
DOI：
10.1111/j.1600-0765.1985.tb00406.x
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发表时间：
1985
影响因子：
3.5
通讯作者：
Skobe,Z
中科院分区：
文献类型：
--
作者：
Peros,WJ;Etherden,I;Gibbons,RJ;Skobe,Z
测定了在亚致死浓度四环素存在下生长对粘性放线菌和牙龈拟杆菌（两种经常从快速进展的牙周炎患者中分离的菌株）的菌毛化程度和表面疏水性的影响。阴性染色的A.粘性菌株LY7和S2以及B.与未处理的对照相比，当在50%最小抑制浓度的四环素存在下生长时，牙龈菌菌株381显示出其表面上菌毛数量的显著减少。使用固定的镧染色薄切片进行了类似观察。除长菌毛外，A.粘菌表面有染色较深的毛簇，不受四环素的影响。抗生素grownA的疏水性。粘性湾还发现牙龈炎细胞显著减少。结果表明，A.粘性湾当在低浓度四环素存在下生长时，牙龈炎可以解释它们附着到实验薄膜的能力降低。这些观察结果表明，四环素治疗破坏性形式的牙周病的疗效的一部分可能是介导的龈下细菌的粘附特性的改变，影响其定植。
The effect of growth in the presence of sublethal concentrations of tetracycline on the extent of fimbriation and surface hydrophobicity of strains ofActinomyces viscosusandBacteroides gingivalis, two species frequently isolated from patients with rapidly progressing periodontitis, was determined. Negatively‐stained cells ofA. viscosusstrains LY7 and S2 andB. gingivalisstrain 381 showed a dramatic reduction in the number of fimbriae on their surface when grown in the presence of 50% of the minimum inhibitory concentration of tetracycline as compared to untreated controls. Similar observations were made with fixed, lanthanum‐stained thin sections. In addition to long fimbriae, theA. viscosusstrains possessed stubby, densely staining tufts on their surface which were not affected by tetracycline. The hydrophobicity of antibiotic‐grownA. viscosusandB. gingivaliscells was also found to be significantly reduced. The decrease in fimbriation and surface hydrophobicity ofA. viscosusandB. gingivaliswhen grown in the presence of low concentrations of tetracycline may explain their reduced ability to attach to experimental pellicles. These observations suggest that part of the efficacy of tetracycline therapy for destructive forms of periodontal diseases may be mediated by an alteration of the adhesive properties of subgingival bacteria which affected their colonization.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
--
发表时间：
1979
期刊：
Reviews of Infectious Diseases
影响因子：
--
作者：
K. Vosbeck;H. Handschin;E. B. Menge;O. Zak
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作者：
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