Adaptation shifts preferred orientation of tuning curve in the mouse visual cortex.
Adaptation shifts preferred orientation of tuning curve in the mouse visual cortex.
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DOI：
10.1371/journal.pone.0064294
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Molotchnikoff S
中科院分区：
文献类型：
--
作者：
Jeyabalaratnam J;Bharmauria V;Bachatene L;Cattan S;Angers A;Molotchnikoff S
在额叶化的哺乳动物中，已经证明适应在频繁或更频繁地呈现非偏好刺激之后产生神经元的取向调谐曲线的峰值的移动。根据适应的持续时间，移位是吸引的（朝向适配器）或排斥的（远离适配器）。小鼠表现出盐和胡椒皮质组织的方向图，因此，这个物种可能会对适应不同。为了检验这个问题，我们确定了12分钟的适应一个特定的方向对麻醉小鼠V1神经元方向调谐曲线的影响。以常规方式记录V1神经元的多单位活动。用正弦波漂移光栅刺激细胞，其取向呈阶梯状倾斜。结果显示，与猫和猴相似，大多数细胞将其最佳方向转移到适配器的方向，而一小部分细胞则表现出排斥性转移。此外，最初untuned细胞表现出不良的调谐曲线反应，以适应显示尖锐的取向选择性。尽管视皮层的组织模式不同，但适应后细胞特性的改变似乎是所有哺乳动物中观察到的普遍现象。本研究对理解脑可塑性的机制通路具有针对性。
In frontalized mammals it has been demonstrated that adaptation produces shift of the peak of the orientation tuning curve of neuron following frequent or lengthier presentation of a non-preferred stimulus. Depending on the duration of adaptation the shift is attractive (toward the adapter) or repulsive (away from the adapter). Mouse exhibits a salt-and-pepper cortical organization of orientation maps, hence this species may respond differently to adaptation. To examine this question, we determined the effect of twelve minutes of adaptation to one particular orientation on neuronal orientation tuning curves in V1 of anesthetized mice. Multi-unit activity of neurons in V1 was recorded in a conventional fashion. Cells were stimulated with sine-wave drifting gratings whose orientation tilted in steps. Results revealed that similarly to cats and monkeys, majority of cells shifted their optimal orientation in the direction of the adapter while a small proportion exhibited a repulsive shift. Moreover, initially untuned cells showing poor tuning curves reacted to adaptation by displaying sharp orientation selectivity. It seems that modification of the cellular property following adaptation is a general phenomenon observed in all mammals in spite of the different organization pattern of the visual cortex. This study is of pertinence to comprehend the mechanistic pathways of brain plasticity.
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影响因子：
25
作者：
McCurry, Cortina L.;Shepherd, Jason D.;Tropea, Daniela;Wang, Kuan H.;Bear, Mark F.;Sur, Mriganka
通讯作者：
Sur, Mriganka
影响因子：
2.5
作者：
MANGINI, NJ;PEARLMAN, AL
通讯作者：
PEARLMAN, AL
影响因子：
2.4
作者：
Nemri A;Ghisovan N;Shumikhina S;Molotchnikoff S
通讯作者：
Molotchnikoff S
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
影响因子：
1.7
作者：
Bachatene, Lyes;Bharmauria, Vishal;Molotchnikoff, Stephane
通讯作者：
Molotchnikoff, Stephane