Hepcidin response to three consecutive days of endurance training in hypoxia
Hepcidin response to three consecutive days of endurance training in hypoxia
复制标题
铁调素对连续三天缺氧耐力训练的反应
DOI：
10.1007/s00421-021-04599-3
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发表时间：
2021
影响因子：
3
通讯作者：
Goto Kazushige
中科院分区：
文献类型：
--
作者：
Sumi Daichi;Hayashi Nanako;Yamaguchi Keiichi;Badenhorst Claire E.;Goto Kazushige
PurposeThe目的是本研究的目的是确定连续3天的耐力训练在缺氧hepcidin responses.Methodnine积极的健康男性完成了两项试验，包括连续3天的耐力训练，无论是缺氧[吸入氧分数（FiO 2）：14.5%）或常氧（FiO 2：20.9%）。在第1-3天，受试者每天进行一次90分钟的耐力训练，包括高强度耐力间歇运动[10 × 4分钟的蹬踏，最大摄氧量（O2 max）为80%，2分钟的主动休息，O2 max为30%]，随后进行30分钟的连续运动，O2 max为60%。在实验期间每天运动前采集静脉血样本（第1-4天）测定血清铁调素、铁、铁蛋白、触珠蛋白和酮体浓度。（p< 0.0001），铁蛋白（p= 0.005）和酮体（p< 0.0001）浓度在两个试验中在第2-4天与第1天相比显著增加，试验之间没有显著差异。在两项试验中，在整个实验期间均未观察到血清结合珠蛋白浓度的显著变化。与第1天相比，2-4天的血清铁调素浓度也显著升高（p= 0.004），但两组间差异无统计学意义。结论与常氧耐力训练相比，连续3天的低氧耐力训练对血清铁调素浓度无影响。
PurposeThe purpose of this study was to determine the effects of 3 consecutive days of endurance training in hypoxia on hepcidin responses.MethodNine active healthy males completed two trials, consisting of 3 consecutive days of endurance training in either hypoxia [fraction of inspired oxygen (FiO2): 14.5%) or normoxia (FiO2: 20.9%). On days 1–3, participants performed one 90 min session of endurance training per day, consisting of high-intensity endurance interval exercise [10 × 4 min of pedaling at 80% of maximal oxygen uptake (O2max) with 2 min of active rest at 30% ofO2max] followed by 30 min of continuous exercise at 60% ofO2max. Venous blood samples were collected prior to exercise each day during the experimental period (days 1–4) to determine serum hepcidin, iron, ferritin, haptoglobin, and ketone body concentrations.ResultSerum iron (p< 0.0001), ferritin (p= 0.005) and ketone body (p< 0.0001) concentrations increased significantly in both trials on days 2–4 compared with day 1, with no significant differences between trials. No significant changes in serum haptoglobin concentrations were observed throughout the experimental period in either trial. Serum hepcidin concentrations also increased significantly on days 2–4 compared with day 1 in both trials (p= 0.004), with no significant differences observed between trials.Conclusion3 consecutive days of endurance training in hypoxia did not affect hepcidin concentrations compared with endurance training in normoxia.
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影响因子：
4.7
作者：
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DOI：
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2002-12-01
影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1016/s0006-291x(88)81056-8
发表时间：
1988-08-30
影响因子：
3.1
作者：
MOSHAGE, HJ;ROELOFS, HMJ;YAP, SH
通讯作者：
YAP, SH