Bone as a possible target of chemical toxicity of natural uranium in drinking water.
Bone as a possible target of chemical toxicity of natural uranium in drinking water.
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DOI：
10.1289/ehp.7475
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发表时间：
2005-01
影响因子：
10.4
通讯作者：
Saha H
中科院分区：
文献类型：
--
作者：
Kurttio P;Komulainen H;Leino A;Salonen L;Auvinen A;Saha H
铀在骨骼中蓄积，影响实验动物的骨骼代谢，并且在饮用水中摄入铀会增加骨骼结构中重要成分钙和磷酸盐的尿排泄。然而，人们对人体摄入天然铀对骨骼的影响知之甚少。我们研究了146名男性和142名女性，年龄在26-83岁之间，他们平均有13年的时间使用来自基岩井的饮用水，这些井位于天然铀含量高的地区。骨形成的生化指标为血清骨钙素和I型前胶原氨基末端前肽，骨吸收的生化指标为血清I型胶原羧基末端末端肽（CTx）。对铀接触的主要测量是饮用水中的铀浓度，另外还有关于铀摄入量和尿液中的铀浓度的资料。对男性和女性的数据分别进行鲁棒回归（抑制潜在影响观察值的贡献）模型分析，并调整年龄、吸烟和雌激素的使用。饮用水中铀浓度中位数为27 μg/L（四分位数区间为6 ~ 116 μg/L）。日铀摄入量中位数为36 μg (7 ~ 207 μg)，累积摄入量为0.12 g （0.02 ~ 0.66 g）。有迹象表明，CTx （p = 0.05）和骨钙素（p = 0.19）的升高可能与男性铀暴露（水中和摄入量中的铀）增加有关，但在女性中没有发现类似的关系。因此，骨骼可能是铀对人体化学毒性的靶点，需要对天然铀对骨骼的影响进行更详细的评估。
Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142 women 26–83 years of age who for an average of 13 years had used drinking water originating from wells drilled in bedrock, in areas with naturally high uranium content. Biochemical indicators of bone formation were serum osteocalcin and amino-terminal propeptide of type I procollagen, and a marker for bone resorption was serum type I collagen carboxy-terminal telopeptide (CTx). The primary measure of uranium exposure was uranium concentration in drinking water, with additional information on uranium intake and uranium concentration in urine. The data were analyzed separately for men and women with robust regression (which suppresses contributions of potential influential observations) models with adjustment for age, smoking, and estrogen use. The median uranium concentration in drinking water was 27 μg/L (interquartile range, 6–116 μg/L). The median of daily uranium intake was 36 μg (7–207 μg) and of cumulative intake 0.12 g (0.02–0.66 g). There was some suggestion that elevation of CTx (p = 0.05) as well as osteocalcin (p = 0.19) could be associated with increased uranium exposure (uranium in water and intakes) in men, but no similar relationship was found in women. Accordingly, bone may be a target of chemical toxicity of uranium in humans, and more detailed evaluation of bone effects of natural uranium is warranted.
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影响因子：
10.4
作者：
Kurttio, Paivi;Auvinen, Anssi;Salonen, Laina;Saha, Heikki;Pekkanen, Juha;Makelainen, Ilona;Vaisanen, Sari B;Penttila, Ilkka M;Komulainen, Hannu
通讯作者：
Komulainen, Hannu
影响因子：
3.5
作者：
Aoshima, K;Fan, JJ;Kasuya, M
通讯作者：
Kasuya, M
DOI：
10.1080/00039890209601415
发表时间：
2002-07-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Sylvester, PLD;L贸pez, R;Cabrini, RL
通讯作者：
Cabrini, RL
影响因子：
8.3
作者：
Jin, TY;Nordberg, G;Bernard, A
通讯作者：
Bernard, A
影响因子：
8.3
作者：
KIDO, T;NOGAWA, K;NAKAGAWA, H
通讯作者：
NAKAGAWA, H